Penfigóide Bolhoso Induzido Por Fármaco: Um Relato De Caso

Abstract

Bullous pemphigoid is the most common autoimmune dermatosisthat can be caused by drugs. The objective of this study was followingthe evolution of a patient with pharmacodermia in use of several drugs. A female patient was treated in a hospital in the city of Presidente Prudente, presenting intact and broken blisters, require etiological investigation. Other diagnostic hypotheses such as porphyria cutanea tarda were ruled out, and the diagnosis of bullous pemphigoid of pharmacological etiology was suggested through cutaneous biopsy of a blister. We stopped using antibiotics and kept the medication in continuous use. It wasintroduced oral prednisone and topical dexamethasone, and it was possible to observe a favorable evolution of the condition, without intercurrences and reduction of the blisters until only residual lesions remained. By analyzing the variables of the case it is assumed that the quinolones were responsible for the condition, emphasizing the importance of knowing the drug reactions to guarantee an early diagnosis.

Abordagens no tratamento de penfigóide bolhoso

“…Os sinais e sintomas são inespecíficos, podendo ainda haver eczematosa, urticária, pápulas e prurido (da Silveira et al, 2020). Normalmente as bolhas são grandes, em comum de 1 a 4 cm, e tensas, com material de conteúdo claro e às vezes hemorrágico devido à destruição de capilares intercalados do procedimento de separação da camada subepidérmica (Lonchiati et al, 2020). Não há prova de um problema genético no desencadeamento desta patologia, e os casos aparecem esporadicamente.…”