26.8% and at the age 0f 15-24 years is 30.2%. Government initiatives to prevent anemia by dispensing iron supplements without teaching have left adolescent girls with little knowledge of anemia, necessitating substantial informative efforts through social media. Instagram is less popular than Whatsapp as a tool for educating adolescent girls about anemia. The purpose of this study is to compare the effects of WhatsApp and Instagram as instructional media on knowledge, attitudes, and eating patterns among adolescent girls in order to prevent anemia. This study employed a control group and a pre-test post-test quasi-experimental design. In this study, participants (n = 60) were split into two groups: the intervention group (n = 30) used Instagram at Junior High School 30 Makassar, while the control group (n = 30) used WhatsApp at Junor High School 14 Makassar. A general questionnaire and a food frequency questionnaire were used to collect the data, which was then analyzed using the repeated ANOVA test to compare each group's results before and after the intervention and the unpaired t-test to compare the Instagram group to the WhatsApp group. The findings indicated that the Instagram group's knowledge (61.50+82.67 vs 82.67+11.651), attitude (81.93+8.682 vs 89.23+6.683), and eating behaviors (467.10+197.269 vs 486.45+212.911) had different values before and after the intervention. In the WhatsApp group, these differences were 54.17+10.093 vs. 60.83+13.714 for knowledge, 73.20+10.179 vs. 83.40+13.255 for attitude, and 553.10+204.985 vs. 518.28+161.929 for eating habits. With a p-value of 0.05, there were differences between the WhatsApp and Instagram groups in terms of knowledge (0.000), attitude (0.000), and eating habits (0.002). Therefore, this study's conclusion is that educating adolescents using Instagram as a medium is more effective in improving their knowledge, attitudes, and eating habits.