Pengaruh Infusa Teh Hitam (Camelia Sinensis) Terhadap Gambaran Histopatologi Hepar, Renal Dan Jumlah Sel-Sel Alfa Dan Beta Pankreas Tikus Jantan Spraguedawley Diinduksi Etanol 20%

Rosalia, Ayu; Indrasari, Maria Chrisna; Tangsilan, Maria Anasthasia; Jayadi, Tejo; Danu, Sulanto Saleh

doi:10.21460/bikdw.v2i1.36

Cited by 3 publications

(6 citation statements)

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“…Theaflavin and epigallocatechin gallate those which are widely contained in black tea acts as intermediary in the protection mechanism of renal tubular epithelial cells, so that the tubules can be protected from free radicals and oxidative stress. 12 The antioxidant content in black tea will automatically donate one of its electrons to free radicals, thereby reducing the damaging power of free radicals and can inhibit cell damage.…”

Section: Analysis Of Mean Tubular Histopathology Score Of Experimenta...mentioning

confidence: 99%

“…11 The type of tea widely consumed, especially in Indonesia, is black tea. 12 The bioactive compound of black tea are thearubigins, theaflavins, a strong group of polyphenols, namely epigallocatechin gallate, the amino acid L-theanine, flavonols, and catechins. 10,11,13 The ingredients in this tea can inhibit free radicals and protect organs from oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil

Taurina¹,

Yuniar²,

Yunita³

2021

J. prof. medika

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Used cooking oil is cooking oil that has been heated repeatedly, so that it can cause the formation of free radical compounds. Free radicals are toxic kidneys that generate cell injury via lipid peroxidation, DNA damage, and protein peroxidation. Black tea (Camellia sinensis) infusion has a strong polyphenol group, namely epigallocatechin gallate, thearubigin, theaflavin, the amino acid L-theanine, flavonols, and catechins that can inhibit free radicals and protect organs from oxidative stress. This study was a post-only control group design experiment. The research subjects used were 24 Sprague Dawley male rats which were divided into six groups. The first group was the control group (K0). Treatment group 1 was given distilled water and used cooking oil after 12 times heating (K1), treatment group 2 was given black tea at a dose of 2.5g/ kg bw (body weight) and distilled water (K2), and treatment group 3 was given black tea at a dose of 3.75 g/kg bw and distilled water (K3). Treatment group 4 was given used cooking oil after 12 times heating and black tea with a dose of 0.50 gr/200 gr bw (K4), treatment group 5 was given used cooking oil after 12 times heating and black tea with a dose of 3.75 g/kg bw (K5). All groups were treated for 42 days. Then, the rats' kidney was collected, and data were analyzed by Kruskal Wallis and One Way ANOVA test. The results of the Kruskal Wallis and One Way ANOVA test showed a decrease in glomerular and tubular damage after the rats orally induced with black tea were given 12x heating used cooking oil (p<0.05). The mean histopathological score in the administration of black tea at a dose of 3.75 g/kg bw was lower than at a dose of 2.5 g/kg bw. This study shows that infusion of black tea (Camellia sinensis) can prevent glomerular and tubular damage induced by used cooking oil.

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Section: Analysis Of Mean Tubular Histopathology Score Of Experimenta...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil

Taurina¹,

Yuniar²,

Yunita³

2021

J. prof. medika

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“…Penggunaan konsumsi teh rumah tangga di indonesia tahun 2019 diproyeksikan sebesar 102.554 Ton dan tingkat produksi teh Indonesia di dunia yaitu urutan ke delapan terbesar di dunia dan urutan kedua terbesar di ASEAN 8 . Jenis teh yang banyak dikonsumsi dimasyarakat adalah teh hitam, kemudian teh hijau 17 . Teh mengandung enam kelompok bioflavanoid yang memiliki aktifitas antioksidan yang beberapa puluh kali lebih kuat dibandingkan α-tocopherol, vitamin C, dan β-carotene.…”

Section: Pendahuluanunclassified

“…Selain menghambat siklooksigenase dan mengurangi produksi prostaglandin, OAINS dapat menyebabkan kerusakan mukosa dengan merekrut leukosit-leukosit sehingga menghasilkan ROS. Pada beberapa penelitian lainnya didapakan bahwa infusa teh hitam memperbaiki gambaran histopatologi hepar dan ginjal, serta meningkatkan jumlah sel-sel alfa dan sel-sel beta pancreas pada tikus putih galur Sprague dawley yang diberi etanol 20% kronik 17 . Antioksidan utama dalam teh adalah catechins, theaflavins, the arubigins, oxyaromatic acids, flavonols, flavones, dan derivac gallic acid 2 .…”

Section: Pembahasan a Hasil Uji Dari Minyak Jelantahunclassified

Pengaruh pemberian teh hitam (camellia sinensis) terhadap gambaran histopatologi gaster tikus putih (Rattus norvegicus) jantan Sprague dawley yang diinduksi minyak jelantah

Akbar,

Sari,

Massardi

2021

juke

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Latar Belakang: Minyak jelantah atau minyak goreng bekas adalah minyak yang digunakan secara berulang tanpa penambahan minyak goreng baru. Pemakaian minyak berulang kali dapat merusak struktur kimia dan menghasilkan radikal bebas. Hasil dari proses tersebut adalah senyawa toksik seperti hidroperoksida. Teh mengandung enam kelompok bioflavanoid catechins, theaflavins, the arubigins, oxyaromatic acids, flavonols, flavones, dan derivac gallic acid yang dapat menghambat radikal bebas, melindungi organ dari stress oksidatif. Teh hitam selain mengandung katekin juga mengandung theaflavin dan thearubigin sebagai hasil dari proses oksidasi enzimatik yang lebih tinggi dibandingkan dengan teh hijau. Metode: Penelitian ini menggunakan metode penelitian eksperimental post test only control grup design dengan menggunakan 24 tikus Sprague dawley jantan dibagi dalam 6 kelompok secara acak dan diberi perlakuan selama 7 minggu. K0 (control) (diberi aquadest), K1 (diberi minyak jelantah 12 kali penggorengan 1,5 ml/hari, 1 jam kemudian diberi aquadest), K2 (diberi infusa teh hitam dengan dosis 0,50 gr/200grBB), K3 ( diberi infusa teh hitam dengan dosis 0,75 gr/200grBB), K4(diberi minyak jelantah 12 kali penggorengan 1,5 ml 1 jam kemudian diberi infusa teh hitam dengan dosis 0,50 gr/200grBB) K5 (diberi minyak jelantah 12 kali penggorengan 1,5 ml 1 jam kemudian diberi infusa teh hitam dengan dosis 0,75 gr/200grBB), setiap hari selama 6 minggu. Pada akhir penelitian tikus dilakukan terminasi dan diambil lambungnya untuk pembuatan preparat histopatologi dengan pewarnaan Hematoksilin Eosin. Data dianalisis dengan uji Kruskal-Wallis dan uji Post Hoc Mann-Whitney. Hasil: Hasil uji Kruskal-Wallis diperoleh nilai p=0,063, yang artinya tidak terdapat perbedaan bermakna dari skor histopatologi antar kelompok. Hasil uji Post Hoc Mann-Whitney menunjukkan tidak terdapat perbedaan bermakna K0 terhadap K1 yang berarti pemberian minyak jelantah 12 kali pemanasan tidak merusak gambaran histopatologi lambung ditinjau secara statistik. Perbandingan antara K0 dengan K2 dan K3 tidak terdapat perbedaan bermakna yang artinya dosis yan diberikan tidak merusak gambaran histopatologi lambung. Perbandingan antara K0 dengan K4 dan K5 menunjukkan tidak terdapat perbedaan bermakna yang artinya pemberian infusa teh hitam (Camellia sinensis) dosis 0,50 gr/200 grBB dan dosis 0,75 gr/200 grBB tidak terjadi perbaikan terhadap kerusakan gaster tikus putih. Kesimpulan: Penelitian membuktikan bahwa Induksi minyak jelantah dengan 12x pemanasan berulang tidak menyebabkan kerusakan pada gaster tikus Rattus norvegicus dan pemberian infusa teh hitam (Camellia sinensis) dosis 0,50 gr/200 grBB dan dosis 0,75 gr/200 grBB tidak terjadi perbaikan terhadap kerusakan gaster tikus putih.

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“…Green tea is used to decrease obesity (Purwanto, Darmawati, Purwaningsih, & Ners, 2014;Rahmanisa & Wulandari, 2016;Sari, 2015), dia-Copyright ©2019 ISEKI-Food Association (IFA) 10. 7455/ijfs/8.2.2019.a5 Nomenclature STZ Streptozotocin NA Nicotinamide BW Body Weight GOD/PAP/POD Enzymatic colorimetric method betes (Bait, 2010;Cheng, Shen, & Wu, 2009;Efendi, Damayanthi, Kustiyah, & Kusumorini, 2010;Holidah, Yasmin, & Christianty, 2018;Ilma, 2016;Rohdiana, Firmansyah, Setiawati, & Yunita, 2012;Wibowo, Kusmana, Suryani, Hartati, & Oktadiyani, 2009;Yilmazer-Musa, Griffith, Michels, Schneider, & Frei, 2012); black tea to treat diabetes (Bait, 2010;Deswati & Nur Maryam, 2017;Holidah et al, 2018;Rosalia, Indrasari, Tangsilan, Jayadi, & Danu, 2017); white tea to treat diabetes (Trinoviani, Kholisoh, Ar-Rifa, & Rustamsyah, 2016) and kombucha green tea is used as a hepato protective agent. The role of tea in health is related to the presence of beneficial compounds such as polyphenol, theophylline, flavonoids, tannins, Vitamin C and E, catechins and some minerals (Majid & Nurkholis, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic activity of herbal green tea extract from white mangrove (Avicennia marina) leaves towards blood glucose level of diabetic wistar rats (Rattus novergicus)

Hardoko

Nafi’ah²,

Sasmito³

et al. 2019

IJFS

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Green tea Camellia sinensis contains polyphenol that has antidiabetic activity. Mangrove leaves also contain polyphenol which potentially gives these leave antidiabetic activity. The aim of this research was to determine the ability of herbal green tea extract from white mangrove (Avicennia marina) leaves to decrease blood glucose level of diabetic Wistar rats (Rattus novergicus). The method used was experimental and involved giving a herbal green tea extract from white mangrove leaves with concentration of 100, 200 and 300 mg/200g BW/day, and positive control, i.e. glybenclamide (0.09 mg/200 g BW/day), to diabetic rats injected with Streptozotocin (STZ) and Nicotinamide (NA). The rats were observed on day 0, 5, 10 and 15. The results showed that the herbal green tea extract from white mangrove leaves decreased the blood glucose level of diabetic rats. The effective extract dose that decreased the blood glucose level of diabetic rats was 300 mg/200 g BW, which is comparable to the effect produced by glybenclamide (antidiabetic medicine). This dose could decrease the blood glucose level of diabetic rats to reach a normal blood glucose level after 20 days.

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Pengaruh Infusa Teh Hitam (Camelia Sinensis) Terhadap Gambaran Histopatologi Hepar, Renal Dan Jumlah Sel-Sel Alfa Dan Beta Pankreas Tikus Jantan Spraguedawley Diinduksi Etanol 20%

Cited by 3 publications

References 0 publications

The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil

The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil

Pengaruh pemberian teh hitam (camellia sinensis) terhadap gambaran histopatologi gaster tikus putih (Rattus norvegicus) jantan Sprague dawley yang diinduksi minyak jelantah

Antidiabetic activity of herbal green tea extract from white mangrove (Avicennia marina) leaves towards blood glucose level of diabetic wistar rats (Rattus novergicus)

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