Pengaruh Konsentrasi Surfaktan Terhadap Karakteristik Fisik Nanoemulsi Dan Nanoemulsi Gel  Koenzym Q10

Wulansari, Silvi Ayu; Sumiyani, Ririn; Aryani, Ni Luh Dewi

doi:10.20473/jkr.v4i2.16164

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…The mixing temperature of the material is a factor that can affect the viscosity value. According to [30], the process of mixing materials using low temperatures can increase the viscosity value. The choice of the type of surfactant is also one of the factors that can affect the viscosity value.…”

Section: Ph Testmentioning

confidence: 99%

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Sapiun

Imran

DEWI³

et al. 2023

Int J App Pharm

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Objective: Sesewanua leaves contain alkaloid compounds as antioxidants, and its leaves can be used to formulate SNEDDS dosage forms, which can effectively deliver the medicine. This study intended to determine the variation of surfactant concentration (Tween 80) and cosurfactant (PEG 400) towards pH, viscosity, nano-emulsion duration and characterization using PSA method (particle size and polydispersity index). Methods: This study employed a quasi-experimental method and the independent variables in this study were variations in the concentration of surfactant (Tween 80) and cosurfactant (PEG 400), which consist of 3 formulas, such as SFS 1 (6:3), SFS 2 (7:2), and SFS 3 (8:1). The dependent variables in this study including pH, viscosity, nano-emulsion time, particle size and polydispersity index which utilized One Way Anova Post Hoc LSD (p>0.05) and Tamhane (p<0.05) tests as the data analysis. Results: The pH test SFS1-SFS3 has a pH value of 7.92, 8.30 and 8.35, followed by Viscosity test SFS1-SFS3, which has a viscosity value of 1.00 cP, 1.38 cP and 2.91 cP. Further, the SFS1-SFS3 nano emulsified time test had nano emulsified time in gastric and intestinal fluids 35.18s and 43.96s, 43.54s and 47.13s and 44.00s and 50.29s. Characterization of SFS1-SFS3 particle size in gastric and intestinal fluids 23.9 nm and 23.0 nm, 18.5 nm and 22.7 nm and 19.1 nm and 22.9 nm, while characterization of SFS1-SFS3 polydispersity index in gastric and intestinal fluids were 0.433 and 0.348, 0.451 and 0.440 and 0.568 and 0.462. Conclusion: The increase of variations in surfactant concentration and decreased cosurfactant significantly affected pH, viscosity, nano-emulsion time, and particle size of SFS preparations. However, the polydispersity index was not considerably affected.

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Section: Ph Testmentioning

confidence: 99%

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Sapiun

Imran

DEWI³

et al. 2023

Int J App Pharm

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“…According to (Hartono & Widiatmoko, 1993), this is due to the influence of additional ingredients that can affect the viscosity of a preparation, such as glycerin and propylene glycol. Apart from that, variations in surfactant concentration can also affect the viscosity of a preparation but do not affect the pH of the preparation (Wulansari et al, 2019). The results of the viscosity test table can be seen in Table 4.…”

Section: Evaluation Test Of Temu Blenyeh Ethanol Extract Mouthwashmentioning

confidence: 99%

Antimicrobial Activity Of Mouthwash Ethanol Extract of Curcuma purpurascens Bl. (Temu Blenyeh) as Affected by Sodium Lauryl Sulfate Concentration Variations

Laili,

Pramiastuti,

Fahamsya

2023

jmpi

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Oral and dental health problems are usually caused by pathogenic microbes such as Streptococcus mutans and Candida albicans. Sodium lauryl sulfate is a foamer that can remove microorganisms in the oral cavity. Using mouthwash is considered the easiest and most effective because it can reach between the teeth. Therefore, the aim of this research is to create and see the effect of varying the concentration of sodium lauryl sulfate in mouthwash preparations of ethanol extract of temu blenyeh (Curcuma purpurascens Bl.) on inhibiting the growth of microbes such as Streptococcus mutans and Candida albicans. The results of testing the antimicrobial activity of mouthwash preparations against Streptococcus mutans bacteria were classified as very weak in formulation (0), namely 3.00 mm, then in the medium category, namely in formulation (I) 5.30 mm, formulation (II) 6.66 mm, and formulation (III) 10.33 mm, while the fungus Candida albicans is classified as very weak in formulation (0), namely 4.00 mm. Then it is classified as medium with an average diameter of the inhibition zone, namely formulation (I) of 5.53 mm, formulation (II) of 8.00 mm, and formulation (III) of 8.58 mm. From these results, it can be concluded that there is an effect of using varying concentrations of sodium lauryl sulfate in each formula on the antimicrobial activity of Streptococcus mutans and Candida albicans.

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“…Nilai zeta potensial yang stabil adalah lebih dari + 30 mV dan kurang dari -30 mV. Nilai zeta potensial menunjukkan kekuatan partikel untuk saling tolak menolak untuk menghasilkan dispersi sediaan yang stabil (Wulansari, 2019).…”

Section: Karakteristik Nanopartikelunclassified

Pengaruh Pemberian Suspensi Serbuk dan Nanopartikel Seledri (Apium graveolens) Terhadap Kondisi Kolitis Pada Mencit yang Diinduksi DSS (Dextran Sodium Sulphate)

Saputra

Dewangga

Sahid

et al. 2022

J. Pharm. Sci. Clin. Res.

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Kolitis adalah penyakit yang mekanismenya didasari oleh infiltrasi sel radang ke mukosa saluran cerna. Sejumlah tanaman memiliki aktivitas sebagai antiinflamasi salah satunya adalah tanaman seledri (Apium groveolens). Kandungan fenolik dan flavonoid dari tanaman seledri, berpotensi memberikan efek proteksi pada lambung dan menurunkan iritasi lambung serta berpotensi digunakan sebagai antiinflamasi pada penyakit kolitis. Pengembangan tanaman seledri menjadi suatu bentuk sediaan obat tradisional memiliki beberapa kendala antara lain kelarutan yang kecil dari suatu ekstrak tanaman yang mengakibatkan absorbsi dan bioavailabilitas yang rendah, sehingga perlu dilakukan pengembangan sedian, seperti dalam bentuk nanopartikel. Penelitian ini dilakukan untuk mengetahui efek pemberian Suspensi Serbuk dan Nanopartikel Seledri terhadap kondisi kolitis pada mencit yang diinduksi DSS. Metode penelitian ini menggunakan mencit jantan galur DDY, yang dibagi menjadi 4 kelompok, kelompok 1 diberikan Suspensi Nanopartikel Seledri (NS) dosis 350 mg/kgBB selama 5 hari pada mencit yang diinduksi DSS 4%, kelompok 2 diberikan Suspensi Serbuk Seledri (SS) dosis 700 mg/kgBB selama 5 hari pada mencit yang diinduksi DSS 4%, kelompok 3 diberikan CMC-Na 0,25% selama 5 hari pada mencit yang diinduksi DSS 4%, dan kelompok 4 diberikan 5-Asam Aminosalisilat (5-ASA) dosis 100 mg/kgBB selama 5 hari pada mencit yang diinduksi DSS 4%. Kemudian dilakukan pengamatan skoring indeks aktivitas kolitis. Penelitian ini menunjukkan bahwa seledri dalam bentuk nanopartikel memberikan efek perbaikan pada kondisi kolitis yang signifikan dengan penuruan skor indeks aktivitas kolitis sebesar 73,62% dibandingkan dengan seledri dalam bentuk serbuk (p<0,05).

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Pengaruh Konsentrasi Surfaktan Terhadap Karakteristik Fisik Nanoemulsi Dan Nanoemulsi Gel Koenzym Q10

Cited by 5 publications

References 15 publications

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Antimicrobial Activity Of Mouthwash Ethanol Extract of Curcuma purpurascens Bl. (Temu Blenyeh) as Affected by Sodium Lauryl Sulfate Concentration Variations

Pengaruh Pemberian Suspensi Serbuk dan Nanopartikel Seledri (Apium graveolens) Terhadap Kondisi Kolitis Pada Mencit yang Diinduksi DSS (Dextran Sodium Sulphate)

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