Advances in science and technology have made it possible to carry out an online learning system, especially during the Covid-19 pandemic. Based on needs analysis interviews conducted in 5 high schools in Maumere, East Nusa Tenggara, the main problems encountered were related to the lack of supporting facilities for independent learning activities of students and the difficulty of teachers in providing contextual learning on material that was quite abstract. This study aims to develop an e-UKBM learning media design based on the STEM approach with a PBL model on Virus material for 10th grade, as a solution to the main problems encountered. This study used ADDIE R&D methods which was limited to the Development stage. The feasibility of the application was assessed from the material and media aspects by expert validators and teachers as practitioners. The results showed that the e-UKBM Virus application design was "Very Eligible" in terms of material with percentage 86.66% and "Very Eligible" in terms of media with percentage 83.33%. Thus, the e-UKBM Virus application is declared feasible to be tested on a limited scale with modifications suggested by the validators.