Efforts to optimize the achievement of chemistry learning outcomes are carried out through experimental research by implementing discovery learning strategies for high school students in Mataram and West Lombok Regency. This study specifically aims to examine the effect of the implementation of discovery learning on higher-order thinking skills (critical and creative thinking skills) and students' chemistry learning outcomes. The study population consisted of 131 students and 85 students from one of the public high schools in Mataram and West Lombok Regency, respectively. The sample was determined by purposive sampling, where the number of students selected as a sample from SMA in Mataram was 66 students and the sample from West Lombok Regency were 64 students. In each SMA as a sample, one experimental class and one control class are assigned. In the experimental class, discovery learning is applied, while in the control class, conventional (expository) learning is applied. The data were obtained based on the test results and analyzed using the two difference test with a significance level of 5%. Based on the results of research and data analysis, it is concluded that the implementation of discovery learning strategies has a positive effect on critical thinking skills, creative thinking skills, and chemistry learning outcomes of public high school students in Mataram and West Lombok Regency.