Uterine revolution was a very important process because the mother needs care, and supervision for the recovery of health as before pregnancy. Cases of bleeding are very common and one of the causes is if involution does not proceed normally. This condition causes the mortality and morbidity of puerperal women was still high. The average maternal mortality rate reaches an average of 359 per 100,000 KH [1]. The research objective was to identify the factors that influence the acceleration of uterine involution in postpartum mothers. This research uses analytic survey with cross sectional study design. Sample 38 respondents were taken using non-probability techniques with accidental sampling, and analysis using the chi-square test. The results of the research respondents mostly aged 19-35 years, multiparous parity, exclusive breastfeeding, normal type of labor, respondents mobilized, and most of the rapid uterine involution, and age and type of labor did not affect the acceleration of uterine involution, whereas parity, exclusive breastfeeding, and mobilization affects the acceleration of uterine involution in the puerperium. Suggested the need for monitoring the process of uterine involution to prevent postpartum complications.