Pengaruh Pektin Buah Apel (Malus Sylvestris Mill) Terhadap Kadar LDL Kolesterol pada Tikus Putih Jantan (Rattus Novergicus) Hiperkolesterolemia

Nurman, Zurni; Masrul, Masrul; Sastri, Susila

doi:10.25077/jka.v6i3.757

Cited by 3 publications

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“…Decreased cholesterol absorption in the intestine results in decreased TG synthesis. 8 This study had several limitations. First, it was conducted only in rats.…”

Section: Discussionmentioning

confidence: 93%

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Effect of <em>arum manis</em> mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats

Saputra,

Naufal,

Utomo

et al. 2023

Med J Indones

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BACKGROUND Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of arum manis mango (Mangifera indica L.) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats. METHODS 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method. RESULTS The M-360 group reduced the LDL level (p = 0.015), while the standard treatment group increased the HDL level (p = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (p = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (p = 0.245, 0.328, and 0.454, respectively). CONCLUSIONS M. indica peel extract reduced LDL and TG levels at 360 mg/day.

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“…Decreased cholesterol absorption in the intestine results in decreased TG synthesis. 8 This study had several limitations. First, it was conducted only in rats.…”

Section: Discussionmentioning

confidence: 93%

“…Next, the mango peel flour was extracted at 90-95 o C for 180 min, according to a previous study. 8 After the extraction, the filtrate was cooled and precipitated for 24 hours with 96% ethanol. The precipitate was separated from the solution and placed in an oven at 50 o C for 24 hours.…”

Section: Mango Peel Extract Productionmentioning

confidence: 99%

Effect of <em>arum manis</em> mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats

Saputra,

Naufal,

Utomo

et al. 2023

Med J Indones

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“…Blood cholesterol can decrease if cholesterol is excreted through bile. So that bile is bound by pectin and causes at least bile acids to return to the liver [3].…”

Section: Introductionmentioning

confidence: 99%

Effect ofCarica papayaL. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

Safrida

Sabri

2020

E3S Web Conf.

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This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

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Pengaruh jus jambu biji dan jus apel hijau terhadap penurunan kadar kolesterol

Djamaludin

Tabrani

2020

J.HolHealth

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Efficacy domestic apple (malus domestica) and guava fruit (psidium guajava l.) juices in the management of blood cholesterol levels Background: Hypertension is a chronic condition, which is blood pressure increases in the blood vessels. One of the causes of hypertension is a diet with high fat. High-fat levels occur precipitation of cholesterol. The methods to overcome hyper cholesterol in the blood by pharmacological and non-pharmacological. Method of non-pharmacological to reduce cholesterol levels with consuming guava and green apple juice.Purpose: Known the efficacy domestic apple (Malus domestica) and guava fruit (Psidium guajava L.) juices in the management of blood cholesterol levels.Method: The design of the research used in this study was a quasi-experiment used non-equivalent control group design. The samples were 16 samples. The sampling used a purposive sampling technique. The data analysis used Independent T-Test.Results: The study showed that the average difference of cholesterol levels in the guava juice group was 17,25±17,019 mg/dl. Meanwhile, the green apple juice group was 58,63±39,867 mg/dl. The result of t value = 2,700 and p value = 0,017 (p < 0,05).Conclusion: There was a difference effect of guava juice and green apple juice to cholesterol levels reduction. Suggestions of this study for hyper cholesterol patients to consume green apple juice as a non-pharmacological treatment.Keywords: Cholesterol; Domestic Apple (Malus Domestica); Guava (Psidium guajava L.); Consumption; Juice.Pendahuluan: Hipertensi adalah kondisi kronis dimana mengalami peningkatan tekanan darah pada dinding pembuluh darah. Salah satu penyebab hipertensi yaitu pola makan dengan kadar lemak tinggi. Kadar lemak tinggi menyebabkan terjadi endapan kolesterol. Cara mengatasi kelebihan kolesterol dalam darah dengan farmakologi dan nonfarmakologi. Cara nonfarmakologi menurunkan kadar kolesterol dengan mengonsumsi jus jambu biji dan jus apel hijau.Tujuan: Diketahui perbedaan pengaruh jus jambu biji dan jus apel hijau terhadap penurunan kadar kolesterol.Metode: Rancangan penelitian yang digunakan adalah quasi experiment dengan pendekatan non equivalent control group design. Sampel sebanyak 16 orang. Pengambilan sampel menggunakan teknik purposive sampling. Analisis data menggunakan uji Independent T-Test.Hasil: Hasil penelitian menunjukkan perbedaan rata-rata kadar kolesterol pada kelompok jus jambu biji adalah 17,25±17,019 mg/dl. Sedangkan, pada kelompok jus apel hijau adalah 58,63±39,867 mg/dl. Hasil nilai t = 2,700 dan p value = 0,017 (p < 0,05).Simpulan: Ada perbedaan pengaruh jus jambu biji dan jus apel hijau terhadap penurunan kadar kolesterol. Saran dari penelitian ini diharapkan penderita kolesterol mengonsumsi jus apel hijau sebagai pengobatan non-farmakologi.

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Pengaruh Pektin Buah Apel (Malus Sylvestris Mill) Terhadap Kadar LDL Kolesterol pada Tikus Putih Jantan (Rattus Novergicus) Hiperkolesterolemia

Cited by 3 publications

References 0 publications

Effect of <em>arum manis</em> mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats

Effect of <em>arum manis</em> mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats

Effect ofCarica papayaL. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

Pengaruh jus jambu biji dan jus apel hijau terhadap penurunan kadar kolesterol

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