The specific skills discussed in the research are the leading sectors in the economic system. Medan City and Nias Regency are two areas within the jurisdiction of North Sumatra Province. The two regions have differences in geographical location, making them both have differences in the economy's structure. In terms of economic growth, the two regions showed differences where Medan City is superior in percentage growth. A significant difference between the two regions is the significant difference in the status of the Regional Fiscal Capacity Index. This study aims to identify the leading sectors owned by Medan City and Nias Regency in the 2017-2021 observation period. The method used is descriptive quantitative by using analytical tools in the form of LQ and DLQ analysis, Klasen Typology, Shift-Share Analysis, and Overlay Analysis. The results showed that Medan City does not have a leading sector at all and Nias Regency has one leading sector in the form of the mining and quarrying sector. This study provides recommendations for the Medan City Government and Nias Regency Government to re-evaluate economic policies, especially related to sectors experiencing a slowdown, progressive sectors, and leading sectors in their respective regions.