Water is one of the biggest components from environment and an important aspect of living organism. The source of water that can be used by community to fulfill their needs is river water, but in recent years, the river water is no longer clear. There are various kinds of water pollution/ contamination sources, including waste from community whether it is from household waste or agriculture waste in smaller to bigger scales, or also industrial waste that can cause environment-based diseases such as cholera, dysentery, skin-disease, typhus, and so on that originated from dirty water Furthermore, if the river water has been contaminated with chemicals, especially heavy metals, it can cause severe toxic effects that will lead to death. Therefore, the aim of this research are knowing the quality of river water on Burai Village, Tanjung Baru Subdistrict, Ogan Ilir District, and analyzing the toxic effects that will occur due to the pollution/ contamination. Water examination was conducted in Laboratory of BTKL Palembang and Laboratory of Science and Technology Faculty UIN Raden Fatah Palembang. From the results of examination, it was found that physically the water was colored, smelly, and turbid, also the existance of heavy metals and numbers of high coliform, around >1600/100 mL samples. This is very dangerous because it can contaminate the aquatic biota in the river and the community whose consuming it can lead to disease or even heavy metal poisoning.