This study aims to analyze the effectiveness of learning through the Science, Evironment, Technology and Society (SETS) approach in quantitative experimental research models on learning outcomes. In addition, this analytical research focuses on science learning at the elementary, middle, high school and tertiary levels. The method used to analyze the effectiveness of the SETS-based learning approach is the researcher measuring the effect size of the research articles about the differences or effects of learning with approaches to science, environment, technology, and society and student learning outcomes in science learning both in physics, chemistry, biology, earth and space sciences and science lessons. The type of research used is meta-analysis using data tabulation sheets and instruments analyzed using openMEE software. There were 83 articles selected, however, there were 22 articles that were relevant and in accordance with the research segmentation with a range of publications in the last 5 years (2018 – 2022). The average effect size obtained from each article is high (large effect) so it is interpreted that there is a significant influence between the SETS-based learning approach variables and student learning outcomes in learning science. The research results can provide a reference for teachers that SETS-based learning is very relevant given to students during the learning process.