This study aims to develop practical and effective student worksheets based on Hyperdocs on the collaboration skills of fifth-grade elementary school students in science learning. The development applied an instructional design that was performed in the semester of the 2020/2021 school year involving 28 students (13 male and 15 female). Data collection techniques include a pretest/posttest (10 questions of multiple choice), observation of student and teacher activities, and a questionnaire for students' collaboration skills. The indicators of collaboration skills were contributing actively, working productively, showing flexibility and compromise, managing projects well, showing respect, and showing responsibility. The results showed that the expert assessment of the student's worksheet Hyperdocs-based was 75% with valid criteria, the expert assessment of the practicality of 93.75% in the valid category, the results of the expert assessment on the student response questionnaire the average acquisition of 94.17 valid categories. The developed Hyperdocs-based worksheets have practical values in implementing learning at meetings 1 and 2 of 88.16% and 87.50% with very practical criteria. The student's worksheet Hyperdocs-based development was effective in science learning which was 0.78 with high criteria.