Pengembangan Sediaan Serbuk Antidiabetes dari Kombinasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) dan Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.)

Yulianti, Rizki; Simanjuntak, Partomuan; Purba, Anny Victor

doi:10.33096/jffi.v7i1.593

Cited by 2 publications

(2 citation statements)

References 1 publication

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“…Diabetes melitus merupakan suatu penyakit kronis dimana organ pankreas tidak dapat memproduksi cukup insulin [1], Selain itu penyakit diabetes mellitus juga merupakan kelompok penyakit metabolik yang ditandai dengan meningkatnya kadar glukosa darah melebihi nilai normal dikarenakan kelainan sekresi insulin, kerja insulin atau keduanya [2]. Gejala hiperglikemia ditandai dengan urin berlebih (polyuria), rasa haus berlebih (polydipsia), penurunan berat badan, kadang-kadang cepat merasa lapar (polifagia) dan penglihatan kabur [3].…”

Section: Pendahuluanunclassified

Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes

Sadik

Anwar

2022

JSSCR

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Gotu kola (Centella asiatica L.) is empirically used as a medicinal plant and scientifically it can be used to treat various diseases based on the results of the Scientification of Herbal Medicine. Gotu kola leaf (Centella asiatica L.) is one of the potential medicinal plants that can be used as herbal medicine because it contains various kinds of nutritious compounds. Because of the many benefits of gotu kola leaves, it is necessary to standardize the extract to ensure the quality associated with the identity substance, and the composition of the chemical content whose specifications are stated in the monograph as a quality requirement listed in Materia Medika Indonesia. Standardization includes organoleptic test, identification of chemical content, determination of water soluble extract content, ethanol soluble extract content and other tests, namely seeing the activity of gotu kola as an antidiabetic. The results and data on the characteristics of the specific parameters indicated that the extracts made had met the requirements of the herbal pharmacopoeia, which means that the ethanolic extract of gotu kola had met the standards, and based on activity testing it was known that the leaf of gotu kola (Centella asiatica L.) was efficacious as antidiabetic.

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Section: Pendahuluanunclassified

Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes

Sadik

Anwar

2022

JSSCR

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“…Symptoms of hyperglycemia are characterized by polyuria, polydipsia, weight loss, and sometimes with polyphagia and blurred vision. Decreased growth and susceptibility to certain infections may also accompany chronic hyperglycemia (Yulianti et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Eugenia polyantha leaf extract as an antidiabetic alternative medicine on Rattus norvegicus

Waluyo,

Fikri,

Cahyani

2023

J. Edubiotik

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The public does not yet know the potential of Eugenia polyantha as an alternative medicine for diabetes mellitus. In fact, the content of chemical compounds such as flavonoids in Eugenia polyantha can minimize damage to the pancreas. This study aimed to determine the antidiabetic activity of the ethanolic extract of Eugenia polyantha leaf against streptozotocin-induced Wistar rats. The sample for this study were male white rats of the Wistar strain, consisting of 30 rats. It was divided into 6 test groups, group P1 was negative control (aqua dest), group P2 was positive control (glibenclamide), and group P3, P4, and P5 was treated with 70% ethanol extract of Eugenia polyantha leaf with doses of 312.5, 625 and 1250 mg/kg respectively. The blood glucose level on the 11th day was tested by ANOVA which is then tested by Duncan. The results showed Eugenia polyantha leaf extract has an effect on reducing blood glucose in Wistar rats (Rattus norvegicus) with doses 312.5, 625, and 1250 mg/kg body weight. The most effective dose of 70% ethanol extract of Eugenia polyantha leaf for reducing blood glucose is 1250 mg/kg body weight. Furthermore, the findings of this study can be tested in more depth so that it can be recommended to the public as an alternative medicine for diabetes mellitus in humans.

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Pengembangan Sediaan Serbuk Antidiabetes dari Kombinasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) dan Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.)

Cited by 2 publications

References 1 publication

Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes

Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes

Eugenia polyantha leaf extract as an antidiabetic alternative medicine on Rattus norvegicus

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