Penggunaan Ventilatory Ratio dan Alveolar Dead Space Fraction sebagai Prediktor Mortalitas pada Pasien COVID-19 dengan Acute Respiratory Distress Syndrome

Putra, Muh Kemal; Utariani, Arie; Semedi, Bambang Pujo; Waloejo, Christrijogo Sumartono; Hardiono, Hardiono

doi:10.15851/jap.v9n1.2274

Cited by 2 publications

(3 citation statements)

References 11 publications

(16 reference statements)

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“…The most commonly assessed indices were V D /V T (17 studies, 20 cohorts, n = 9,850) and VR (16 studies, 18 cohorts, n = 10,326). Five studies assessed both V D /V T and VR (27,(29)(30)(31)33). Other indices assessed were end-tidal to arterial carbon dioxide ratio (29,39), corrected minute ventilation (30), and arterial to end-tidal carbon dioxide gradient (28).…”

Section: Resultsmentioning

confidence: 99%

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Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*

Jayasimhan¹,

Chieng²,

Kolbe

et al. 2023

Critical Care Medicine

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OBJECTIVES: Acute respiratory distress syndrome (ARDS) is associated with high ventilation-perfusion heterogeneity and dead-space ventilation. However, whether the degree of dead-space ventilation is associated with outcomes is uncertain. In this systematic review and meta-analysis, we evaluated the ability of dead-space ventilation measures to predict mortality in patients with ARDS. DATA SOURCES: MEDLINE, CENTRAL, and Google Scholar from inception to November 2022. STUDY SELECTION: Studies including adults with ARDS reporting a dead-space ventilation index and mortality. DATA EXTRACTION: Two reviewers independently identified eligible studies and extracted data. We calculated pooled effect estimates using a random effects model for both adjusted and unadjusted results. The quality and strength of evidence were assessed using the Quality in Prognostic Studies and Grading of Recommendations, Assessment, Development, and Evaluation, respectively. DATA SYNTHESIS: We included 28 studies in our review, 21 of which were included in our meta-analysis. All studies had a low risk of bias. A high pulmonary dead-space fraction was associated with increased mortality (odds ratio [OR], 3.52; 95% CI, 2.22–5.58; p < 0.001; I 2 = 84%). After adjusting for other confounding variables, every 0.05 increase in pulmonary-dead space fraction was associated with an increased odds of death (OR, 1.23; 95% CI, 1.13–1.34; p < 0.001; I 2 = 57%). A high ventilatory ratio was also associated with increased mortality (OR, 1.55; 95% CI, 1.33–1.80; p < 0.001; I 2 = 48%). This association was independent of common confounding variables (OR, 1.33; 95% CI, 1.12–1.58; p = 0.001; I 2 = 66%). CONCLUSIONS: Dead-space ventilation indices were independently associated with mortality in adults with ARDS. These indices could be incorporated into clinical trials and used to identify patients who could benefit from early institution of adjunctive therapies. The cut-offs identified in this study should be prospectively validated.

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Section: Resultsmentioning

confidence: 99%

“…Some studies had more than one cohort of patients for derivation and subsequent validation. We included 29 studies comprising 33 cohorts in our systematic review (5, 9, 10, 18–43) and 16 studies comprising 21 cohorts in our meta-analysis ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*

Jayasimhan¹,

Chieng²,

Kolbe

et al. 2023

Critical Care Medicine

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“…In a study conducted by Tushar et al (2020), it was stated that respiratory factors are the strongest predictors of patient mortality in the ICU. The incidence of Acute Respiratory Distress Syndrome (ARDS) in coronavirus disease-19 patients mostly has poor output; , death in coronavirus disease-19 patients with ARDS treated in the ICU room ranges from 21-61.5% even up to 94% (Putra et al, 2021). ARDS is the majority of complications suffered by COVID-19 patients, of which ARDS is the main cause of mortality in coronavirus disease-19 cases (Tomazini et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

relationship between sequential organ failure assessment (SOFA) score and mortality in covid-19 patients with ARDS

Setiyawan,

Octaverlita,

Suryandari

2023

J Kep Padjadjaran

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Background: The WHO declared a COVID-19 pandemic on January 30, 2020. Five percent of all patients with coronavirus disease-19 symptoms are emergency and critical cases of ARDS by 49% mortality. The SOFA score is an assessment in intensive care unit patients to determine the level of organ failure.Purpose:The research aimed to determine the relationship between SOFA scores and mortality in coronavirus disease-19 patients with ARDS.Methods: This type of research was quantitative with a retrospective cohort design. The population was coronavirus disease-19 patients with ARDS in the intensive care unit room at RSUD dr. Moewardi in January-September 2021 with 485 people. Eighty-three (83) respondents were selected through the purposive sampling technique. The research instrument used the SOFA scoring sheet. Results: The study on the characteristics of respondents revealed that 57.8% were male, the average age of respondents was 57.31 years and 57.8% with comorbid diseases. The abnormal SOFA scores were 96.4%, 91.6% mortality. The Chi-Square test showed a p-value of 0.018.Conclusion: There is a relationship between SOFA scores and mortality in coronavirus disease-19 patients with ARDS. SOFA score could be used as a predictor of mortality in coronavirus disease-19 patients with ARDS. SOFA score scores can describe the patient’s prognosis, because SOFA scores have an assessment of all six organ functions such as respiration (PaO2 / FiO2), blood pressure, creatinine and diuresis, bilirubin, platelets, and GCS, so that it is effective in assessing organ failure.

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Penggunaan Ventilatory Ratio dan Alveolar Dead Space Fraction sebagai Prediktor Mortalitas pada Pasien COVID-19 dengan Acute Respiratory Distress Syndrome

Cited by 2 publications

References 11 publications

Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*

Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*

relationship between sequential organ failure assessment (SOFA) score and mortality in covid-19 patients with ARDS

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