Penicillamine as Lead-chelating Substance in Man

The Antipyridoxine Effect of Penicillamine in Man*

“…The Antipyridoxine Effect of Penicillamine in Man * ISRAELI A. JAFFE, KURT Penicillamine is a potent oral chelating agent that is used in the treatment of Wilson's disease and certain heavy metal intoxications (1,2). It is currently under study in primary macroglobulinemia, the cold agglutinin syndrome, rheumatoid arthritis, and cystinuria (3)(4)(5)(6).…”

Exposure of Humans to Lead

“…in comparable doses, EDT A is more effective than PCA (57)(58)(59). When given orally the order of effectiveness is reversed (58,59) gastrointestinal absorption of PCA. The routine use of these agents for prophylactic and diagnostic purposes is somewhat hazardous.…”

Metal binding by pharmaceuticals. Part 5. Interaction of Cd(II), Ni(II) and Pb(II) with the intracellular hydrolysis products of the anti-tumour agent ICRF 159 and its inactive homologue ICRF 192

“…Treatment for plumbism has for many years centred on the use of three agents, EDTA, D-penicillamine and BAL [22][23][24][25][26][27][28]. Unfortunately, none can be considered as the ideal sequestering agent.…”

“…Thus, we can see that both cadmium and nickel could be more effectively chelated by other known agents [20,21]. The curve for lead, however, is to the left of both EDTA and o-penicillamine, both extensively used as lead chelators [22,23]. This means that ICRF 226 would be more effective than EDTA and D-penicillamine, even when administered at a lower total drug concentration, in removing lead(II).…”