Penicillamine-induced elastosis of the mucosal lip

Lewis, Bethany K.H.; Chern, Peggy; Stone, Mary Seabury

doi:10.1016/j.jaad.2008.09.018

Cited by 29 publications

(26 citation statements)

References 15 publications

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“…This may be due to either their true rarity or to being simply overlooked, in particular when they do not comprise the main component of a lesion. A review of the pertinent literature has disclosed only two cases of oral elastofibroma [2,3], and a single case of penicillamine-induced elastosis of the lip mucosa in a patient with Wilson's disease [4].…”

Section: Introductionmentioning

confidence: 99%

Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Tosios

Economou

Vasilopoulos

et al. 2009

Head and Neck Pathol

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Three cases of abnormalities of elastic fibers, two of them on the floor of the mouth and one on the lingual alveolar mucosa, close to the floor of the mouth, in a patient with history of homolateral squamous cell carcinoma of the floor of the mouth, are presented. Comparison with elastofibromatous changes and elastofibromas are made and their possible pathogenesis is discussed. It is suggested that increased awareness may facilitate recognition of such lesions as they can be easily overlooked, especially when they do not present as discrete tumors or they are associated with other ''more significant'' pathologic processes.

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Section: Introductionmentioning

confidence: 99%

Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Tosios

Economou

Vasilopoulos

et al. 2009

Head and Neck Pathol

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“…Most of the adverse effects of D-penicillamine are cutaneous and they occurring in 25∼50% of patients. These adverse effects can be classified into three groups 3 , including early onset morbilliform and urticarial hypersensitivity reactions and later onset bullous and lupus-like autoimmune reactions 9 . The third group of dermopathies is a spectrum of cutaneous elastotic and collagen disorders 3 such as PXE, EPS, cutis laxa and anectoderma 4,5 .…”

Section: Discussionmentioning

confidence: 99%

“…This enzyme is required for the cross-linkage of elastic and collagen fibers in the dermis. The indirect inhibition of the enzyme activity by removal of copper from the tissues by penicillamine causes abnormal elastic fiber accumulation 9 . An alternate or complementary mechanism is direct drug inhibition of the deamination of the lysine residues that are necessary for elastin and collagen maturation 10 .…”

Section: Discussionmentioning

confidence: 99%

Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease

Choi

Kim

et al. 2010

Ann Dermatol

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Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea. (Ann Dermatol 22(4) 468 ∼471, 2010)

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“…1 PEN's therapeutic effectiveness has been investigated and welldocumented. [2][3][4][5][6] Several analytical methods have been developed for PEN determination in pharmaceutical preparations, including spectrophotometry, [7][8][9] voltammetry, 10 potentiometry, 11 amperometry, 12 fluorometry, 13,14 capillary electrophoresis, 15 and chromatography. 16,17 There are several flow systems using a spectrophotometric detector [18][19][20][21] for the determination of PEN, among them, only one is a SIA method based on complex formation between Fe(III) ion and PEN.…”

Section: Introductionmentioning

confidence: 99%