Penicillin allergy label persists despite negative testing

The 3 Cs of Antibiotic Allergy—Classification, Cross-Reactivity, and Collaboration

“…125 ‘De-labelling’ patients via any of these means is only half the battle, as both clinicians and patients often revert to the pre-test labels post-assessment. 63, 129, 130 Although penicillin allergy may be recorded in ≥8% of inpatients, a description in the EMR is often missing (36%). 38 Updating electronic medical records (EMR) and ensuring correct AALs are reinforced or removed post testing is also essential to effect change, 38 yet studies evaluating the impact of the EMR on antibiotic allergy are missing.…”

Patient and Primary Care Physician Perceptions of Penicillin Allergy Testing and Subsequent Use of Penicillin-Containing Antibiotics: A Qualitative Study

“…We identified the potential barriers and facilitators to penicillin prescription and use following negative testing. This is an area not well defined in the literature; studies have highlighted patient anxiety around having a reaction (23)(24)(25)(26), lack of confidence in the safety of penicillin administration (23)(24)(25)(26), or uncertainty about which class of antibiotics could be safely received (27,28). Patients were reassured by having undergone a "thorough" testing process and having a need for a penicillin following a negative test motivated consumption of penicillin; a barrier to consumption was the presence of an allergy label for many years.…”

Improving Antimicrobial Stewardship by Antibiotic Allergy Delabeling: Evaluation of Knowledge, Attitude, and Practices Throughout the Emerging Infections Network

“…Contemporary studies suggest that both outpatient and inpatient AAT programs comprising combinations of SPT/IDT and oral challenge are both cost saving and effective at delabeling patients of antibiotic allergy [1, 14, 15]. Most antibiotic allergy “labels” are inaccurate, because almost 90% of patients with a penicillin allergy history are able tolerate a β-lactam after formal allergy testing [9].…”