Penicillin in Infancy and Childhood

Penicillin V--Clinical Assessment After One Year

“…As there is achlorhydria in infants under 6 months, and a definite diminution of hydrochloric acid in gastric juice has been observed in adult cases of pneumonia, oral penicillin G was expected to be reliable in such cases. This has been reported by Buchanan (1946) and by Anderson and Landsman (1947). Other preparations, such as benzathine penicillin and a combination of penicillin G and probenecid, have been used orally, but there are conflicting reports of the reliability of absorption.…”

Oral Penicillin and Sulphadimidine in Middle-ear Infections

“…There can be no doubt that, when administered on an empty stomach, penicillin is well absorbed from the first part of the duodenum in a dosage some five times in excess of that by injection (Little and Lumb, 1945;Buchanan, 1946;Husson, 1947;Markowitz and Kuttner, 1947;Reisman et al, 1947;Stewart and May, 1947;Cohlan et al, 1948). Hypochlorhydria, occurring as a result of severe illness, contributes to this (Buchanan, 1946;Anderson and Landsman, 1947;Bicknell, 1951).…”

“…Hypochlorhydria, occurring as a result of severe illness, contributes to this (Buchanan, 1946;Anderson and Landsman, 1947;Bicknell, 1951). The adequate clinical effect of oral therapy in serious illnesses such as pneumonia has been amply demonstrated (Bunn et al, 1945;Finland et al, 1945;Suchett-Kaye and Latter, 1947;Anderson and Landsman, 1947;Eadie et al, 1951).…”

The Treatment of Otitis Media

“…Penicillin is given alone in mild cases, combined penicillin and sulphadimidine (Sulphamezathine) to severe cases, and Chloromycetin alone if there is no prompt response to the latter, or if it is indicated as the result of bacteriological examination. The drugs are all given orally; since there is sufficient evidence of the effectiveness of penicillin, when administered on an empty stomach in a dosage some five times in excess of that by injection (Anderson and Landsman, 1951; Buchanan, 1946; Bunn et al , 1945; Cohlan et al , 1948; Eadie et al , 1951; Finland et al , 1948; Husson, 1947; Little and Lumb, 1945; Markowitz and Kuttner, 1947; Reisman et al , 1947; Wheatley, 1951). An eight‐hourly régime has proved entirely effective, and very convenient for the domiciliary patient.…”