Penicillin in the Treatment of Meningitis

Rosenberg, David H.

doi:10.1001/jama.1944.02850330009002

Cited by 46 publications

(9 citation statements)

References 7 publications

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“…A redução da letalidade para 9,0% comparada à letalidade de 22,0% observada nos pacientes tratados com soro, levou à rápida adoção do novo tratamento no mundo todo, tão logo houve disponibilidade de sulfonamidas 5 . Em 1944, médicos da Marinha americana avaliaram a eficácia da penicilina no tratamento de meningites bacterianas obtendo excelentes resultados 6 . No próprio ano de 1944, Peixoto 7 relatou a cura de um caso de meningite cérebro-espinhal com penicilina, no Brasil.…”

Section: Tendência Secularunclassified

A doença meningocócica em São Paulo, Brasil, no século XX: características epidemiológicas

Moraes

Barata

2005

Cad. Saúde Pública

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Section: Tendência Secularunclassified

A doença meningocócica em São Paulo, Brasil, no século XX: características epidemiológicas

Moraes

Barata

2005

Cad. Saúde Pública

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“…The dose of benzyl penicillin we used is lower than the usual recommended dose [5], but this dose has been used at Auckland Hospital and many other New Zealand hospitals for 140 years. We assume that dosages much lower even than our routine 12 MU (7.2 g) per day in the earliest study [1] drove this initial, now historical local decision, which has been perpetuated by successive generations of New Zealand infectious diseases physicians. The similarity of local outcomes to those reported elsewhere and the complete absence of relapse demonstrates its efficacy.…”

Section: Discussionmentioning

confidence: 98%

“…In 1944, Rosenberg and Arling [1] reported recovery in 64 of 65 patients with cerebral fever due to meningococci treated with penicillin (0.12 MU q.d. im or continuous iv infusion, as well as 0.01 MU [6 mg] intrathecally for 8-48 h).…”

mentioning

confidence: 99%

Three Days of Intravenous Benzyl Penicillin Treatment of Meningococcal Disease in Adults

Rb¹,

Galler²,

Roberts

et al. 2003

Clinical Infectious Diseases

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New Zealand has experienced an epidemic of predominantly serogroup B meningococcal disease during the past decade. In a prospective study, we treated adults (age, >15 years) with meningococcal disease with intravenous benzyl penicillin (12 MU [7.2 g] per day) for 3 days. Sixty-one adults with suspected meningococcal disease were consecutively admitted during the 33-month period; 3 patients were excluded. The 58 patients had a mean age (+/- standard deviation [SD]) of 27.9+/-14.5 years (median, 21 years; range, 15-70 years). Forty-four patients had confirmed and 14 patients had probable meningococcal disease. Fifty-seven patients received 12 MU (7.2 g) and 1 received 8 MU (4.8 g) of benzyl penicillin per day. Thirteen patients received additional antibiotics within the first 24 h because of diagnostic uncertainties. Patients received a mean (+/-SD) of 3.0+/-0.5 days of treatment. No patients relapsed. Five patients died. All but 1 death occurred during benzyl penicillin treatment, and the only posttreatment death was not due to meningococcal disease. Three days of intravenous benzyl penicillin is sufficient treatment for adults with meningococcal disease. The usual recommendations for duration of treatment are excessive.

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“…Penicillin passes the blood-brain barrier minimally, but as some already predicted (Rosenberg & Sylvester, 1944;Rosenberg & Arling, 1984), the higher doses resulted in CSF concentrations high enough to be bactericidal. Around 1950, the first results of clinical studies with only high-dosed penicillin administered systemically were published.…”

Section: Penicillinmentioning

confidence: 88%

“…The first reports of large numbers of patients suffering from meningococcal meningitis treated with penicillin came from the American Army (Tauber & Sande, 1984). Only one of these patients died, resulting in a mortality rate of only 1.4% (Rosenberg & Arling, 1984). Because systemically administered penicillin was thought not to reach the central nervous system (Rammelkamp & Keefer, 1943), it was administered both systemically and intrathecally.…”

Section: Sulfonamidesmentioning

confidence: 99%

A History of Acute Bacterial Meningitis

Uiterwijk

Koehler

2012

Journal of the History of the Neurosciences

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Although meningitis was not yet known as such, its symptoms have been conceptualized in different ways and many theories about its causes have been formulated in the course of time. Terms like hydrocephalus and brain fever were used for different clinical manifestations of what today would be recognized as meningitis. Pathological-anatomical findings led to the emergence of the clinical entity from several old concepts of disease. Initially, diagnostic means were limited and therapeutic methods did not differ much from those that had been applied for centuries, even far into the nineteenth century. Discoveries in bacteriology and the introduction of the lumbar puncture provided a new paradigm for knowledge of the pathophysiology and treatment of what then became known with the term meningitis. The development of new therapeutic methods including antiserum, sulfonamides, and penicillin resulted in a decreasing mortality during the past century. Nowadays, with the use of antibiotics, bacterial meningitis can often be cured.

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Penicillin in the Treatment of Meningitis

Cited by 46 publications

References 7 publications

A doença meningocócica em São Paulo, Brasil, no século XX: características epidemiológicas

A doença meningocócica em São Paulo, Brasil, no século XX: características epidemiológicas

Three Days of Intravenous Benzyl Penicillin Treatment of Meningococcal Disease in Adults

A History of Acute Bacterial Meningitis

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