Penicillin in Wound Exudates

Florey, M. E.; Turton, Edward; Duthie, E. S.

doi:10.1016/s0140-6736(46)90933-6

Cited by 26 publications

(6 citation statements)

References 15 publications

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“…Florey et al (1946) were able to demonstrate benzylpenicillin in wound exudates for at least twice as long as in serum; reabsorption of the drug occurred slowly, as demonstrated by the prolonged urinary excretion. B rown (1964) found that, in rats, high serum binding does not in any way retard the passage of a penicillin from site to site nor influence its penetration into inflamma tory exudates and granuloma tissue.…”

Section: Extravascular Fluid Levels and Tissue Distributionmentioning

confidence: 96%

The Prognostic Significance of Penicillin Serum Levels and Protein Binding in Clinical Medicine. A Review of Current Studies

Warren¹

1965

Chemotherapy

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Section: Extravascular Fluid Levels and Tissue Distributionmentioning

confidence: 96%

The Prognostic Significance of Penicillin Serum Levels and Protein Binding in Clinical Medicine. A Review of Current Studies

Warren¹

1965

Chemotherapy

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“…However, in rare instances it may be necessary to rely exclusively on antibiotic therapy. Although it has been shown that adequate concentrations of penicillin are present within abscesses, little information is available regarding activity of other antibiotics within abscesses (4,14).…”

mentioning

confidence: 99%

Interaction of Purulent Material with Antibiotics Used to Treat Pseudomonas Infections

Bryant

Hammond

1974

Antimicrob Agents Chemother

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To define factors contributing to the adverse prognosis of patients with gram-negative bacillemia and abscess formation, we studied the interaction between polymyxin B, colistin sulfate, gentamicin, or carbenicillin with purulent material. Carbenicillin activity was not significantly altered by incubation with pus. Equal volumes of antibiotic and purulent sediment decreased the effective concentration of polymyxin B, colistin sulfate, or gentamicin from 100 yg/ml to 3 to 6 ug/ml. One milliliter of purulent sediment bound more than 700 ,ug of gentamicin and 1,500 ,ug of polymyxin B or colistin sulfate. This effect occurred rapidly, proceeded at 4 and 37 C, was stable for 24 to 48 h, and was altered, but not abolished, by varying the pH of the solution. Antibiotic activity could be removed from pus by high concentrations of protamine sulfate, heparin, sodium chloride, or potassium chloride, suggesting binding rather than inactivation.

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“…penicillin are higher and more persistent in tissues and organs than those in the blood (Schachter, 1948;Rammelkamp and Keefer, 1950), but the practical significance of these findings can probably be ignored. Florey et al (1946) and Ungar (1950) both observed that penicillin administered parenterally could be detected in the exudate from wounds for longer periods than in the blood.…”

Section: Absorption Blood Levels and Excretionmentioning

confidence: 99%

Antibiotics: Their application in veterinary practice

English

1956

New Zealand Veterinary Journal

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Penicillin in Wound Exudates

Cited by 26 publications

References 15 publications

The Prognostic Significance of Penicillin Serum Levels and Protein Binding in Clinical Medicine. A Review of Current Studies

The Prognostic Significance of Penicillin Serum Levels and Protein Binding in Clinical Medicine. A Review of Current Studies

Interaction of Purulent Material with Antibiotics Used to Treat Pseudomonas Infections

Antibiotics: Their application in veterinary practice

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