Penicillin‐resistant Staphylococci in the General Population

Rountree, Phyllis M.; Rheuben, Judith

doi:10.5694/j.1326-5377.1956.tb35408.x

Cited by 25 publications

(6 citation statements)

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“…A comparison of the type distribution in these two series showed that the difference was almost entirely due to the presence of a nasal ' carrier epidemic' of Type 71 (unassociated with any skin infections) in one of the schools sampled in 1955. Unfortunately, no opportunity presented itself for the examination of nasal swabs from entirely unconnected persons, such as the blood donor series of Rountree and her colleagues (see Rountree & Rheuben, 1956).…”

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confidence: 99%

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Parker

1958

J. Hyg.

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1. A collection of 1389 strains ofStaphylococcus aureusof human origin was examined by the following tests: phage typing, antibiotic resistance, ability to inhibit the growth ofCorynebacterium diphtheriae, the egg-yolk reaction and the serum opacity reaction.2. Nearly all strains ofStaph. aureusType 71 were penicillin resistant, inhibitedC. diphtheriae, gave a negative egg-yolk reaction, and produced a zone of opacity on horse-serum agar.3. The penicillin resistance of Type 71 strains is unlikely to have arisen as a result of the therapeutic use of penicillin, and is probably a natural characteristic of the type.4.Staph. aureusstrains which gave a negative egg-yolk reaction and a positive serum opacity reaction occurred almost exclusively in superficial lesions. The majority of them were members of Type 71, or were penicillin-resistant members of phage-group III. It is suggested that these organisms can cause superficial inflammation, but are usually unable to invade deeper tissues.I wish to thank Dr A. J. H. Tomlinson for valuable information about his unpublished work on impetigo. Thanks are also due to many colleagues who have provided cultures and clinical information, to Dr R. E. O. Williams for typing phages, and to Mr L. E. Simmons for technical assistance.

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Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Parker

1958

J. Hyg.

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“…As previously reported, the CC30 S. aureus lineage can be divided into three clusters: Clade 1 (prototype strain 55/2053; PVL-positive and penicillin-resistant MSSA), Clade 2 (prototype strain TCH60; PVL-positive CA-MRSA harboring SCCmec type IV), and Clade 3 (prototype strain MRSA252/EMRSA-16; PVL-negative HA-MRSA harboring SCCmec type II or IV) 20 . Clade 1 strains cause severe infections and were the epidemic strain type in Europe, the United States, and Australia in the 1950s [26][27][28][29][30] . The percent of S. aureus infections caused by Clade 1 strains had dramatically decreased by the mid-1960s, due to methicillin use for the treatment of penicillin-resistant strains 31 .…”

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confidence: 99%

Genetic and phenotypic diversity of methicillin-resistant Staphylococcus aureus among Japanese inpatients in the early 1980s

Zuo

Uehara

et al. 2021

Sci Rep

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To trace the linkage between Japanese healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) strains in the early 1980s and the 2000s onward, we performed molecular characterizations using mainly whole-genome sequencing. Among the 194 S. aureus strains isolated, 20 mecA-positive MRSA (10.3%), 8 mecA-negative MRSA (4.1%) and 3 mecA-positive methicillin-susceptible S. aureus (MSSA) (1.5%) strains were identified. The most frequent sequence type (ST) was ST30 (n = 11), followed by ST5 (n = 8), ST81 (n = 4), and ST247 (n = 3). Rates of staphylococcal cassette chromosome mec (SCCmec) types I, II, and IV composed 65.2%, 13.0%, and 17.4% of isolates, respectively. Notably, 73.3% of SCCmec type I strains were susceptible to imipenem unlike SCCmec type II strains (0%). ST30-SCCmec I (n = 7) and ST5-SCCmec I (n = 5) predominated, whereas only two strains exhibited imipenem-resistance and were tst-positive ST5-SCCmec II, which is the current Japanese HA-MRSA genotype. All ST30 strains shared the common ancestor strain 55/2053, which caused the global pandemic of Panton-Valentine leukocidin-positive MSSA in Europe and the United States in the 1950s. Conspicuously more heterogeneous, the population of HA-MRSA clones observed in the 1980s, including the ST30-SCCmec I clone, has shifted to the current homogeneous population of imipenem-resistant ST5-SCCmec II clones, probably due to the introduction of new antimicrobials.

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“…As previously reported, the CC30 S. aureus lineage can be divided into three clusters: Clade 1 (representative strain 55/2053; PVL-positive and penicillin-resistant MSSA), Clade 2 (representative strain TCH60; PVL-positive CA-MRSA harboring SCCmec type IV), and Clade 3 (representative strain MRSA252/EMRSA-16; PVL-negative HA-MRSA harboring SCCmec type II or IV) [41]. Strains in Clade 1 cause severe infections and had been the epidemic clone in Europe, the United States, and Australia in the 1950s [46][47][48][49][50]. The percent of S. aureus infections caused by Clade 1 strains decreased dramatically by the mid-1960s, resulting from methicillin use for the treatment of penicillin-resistant strains [51].…”

Section: Discussionmentioning

confidence: 99%

Genetic Diversity of Methicillin-Resistant Staphylococcus Aureus Among Japanese Inpatients in the Early 1980s

Zuo

Uehara

et al. 2020

Preprint

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Background: Methicillin-resistant Staphylococcus aureus (MRSA) was recognized as a serious nosocomial pathogen in Japan starting in the early 1980s. Limited genotypic characteristics on healthcare-associated MRSA (HA-MRSA) associated with “hospital MRSA panics” in Japan in this era. Therefore, this study aimed to determine the characteristics of Japanese HA-MRSA strains in the early 1980s and their linkage with current MRSA strains.Methods: For 194 S. aureus strains isolated in the early 1980s, we determined methicillin resistance phenotypically and genotypically and performed multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) typing, and whole-genome sequencing. Results: Twenty mecA-positive MRSA (10.3%), 8 mecA-negative MRSA (4.1%) and 3 mecA-positive methicillin-susceptible S. aureus (MSSA) (1.5%) strains were identified. The frequent sequence type (ST) was ST30 (n=11), followed by ST5 (n=8), ST81 (n=4), and ST247 (n=3). Rates of SCCmec types I, II, and IV were 65.2%, 13.0%, and 17.4%, respectively. ST30-SCCmec I (n=7) and ST5-SCCmec I (n=5) were predominant genotypes. Only two strains exhibited tst-positive ST5-SCCmec II, which is the current Japanese HA-MRSA genotype. Moreover, 73.3% of SCCmec type I strains were susceptible to imipenem compared with SCCmec type II strains (0%). All ST30 strains shared a common ancestor with strain 55/2053, which resulted in a global pandemic of Panto-Valentine leukocidin (PVL)-positive and penicillin-resistant MSSA spread in Europe and the United States in the 1950s. Conclusions: Our results demonstrated the heterogeneous population structure of Japanese HA-MRSA during the early 1980s, which comprised diverse clones that are mostly rare in recent years. The shift to the current homogenous population structure of HA-MRSA strains consisting of tst-positive ST5-SCCmec II might result from the clinical introduction of new antimicrobials including imipenem.

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Penicillin‐resistant Staphylococci in the General Population

Cited by 25 publications

References 9 publications

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Genetic and phenotypic diversity of methicillin-resistant Staphylococcus aureus among Japanese inpatients in the early 1980s

Genetic Diversity of Methicillin-Resistant Staphylococcus Aureus Among Japanese Inpatients in the Early 1980s

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Penicillin‐resistant Staphylococci in the General Population

Cited by 25 publications

References 9 publications

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Some cultural characteristics ofStaphylococcus aureusstrains from superficial skin infections

Genetic and phenotypic diversity of methicillin-resistant Staphylococcus aureus among Japanese inpatients in the early 1980s

Genetic Diversity of Methicillin-Resistant&nbsp;Staphylococcus Aureus&nbsp;Among Japanese Inpatients in the Early 1980s

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Genetic Diversity of Methicillin-Resistant Staphylococcus Aureus Among Japanese Inpatients in the Early 1980s