Penicillin sensitivity

Specific Inhibition of Allergic Reactions to Penicillin in Man by a Monovalent Hapten

“…Indeed, it has been wished since long that some in vitro serological test could be developed for the diagnosis of penicillin allergy and its prevention. Various tests such as the haemagglutination reaction with penicillin-coated erythrocytes [8][9][10], the degranulation of rabbit [11] or rat [12] mast cells in presence of serum from penicillin-allergic patients, the inhibition of activity of bacterio phages coated with penicillin [13], radioimmunoassay of anti-penicillin an tibodies [14], passive anaphylactic reactions (Schulz-Dale) with tissues of various species including man and monkey [15,16] and specific lympho cyte stimulation with penicillin and penicillin derivatives [7] have been proposed as tests for penicillin allergy.…”