Penicillinase-producing Neisseria gonorrhoeae in Riyadh, Saudi Arabia.

Chowdhury, M. N. H.; Pareek, Shiv Shanker; Mahgoub, El Sheikh

doi:10.1136/sti.57.4.256

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…In total, 24 (67 %) isolates showed resistance to penicillin that could result in therapeutic failure. Penicillin resistance has also been reported from Riyadh, Saudia Arabia (12 % PPNG, 13% CMRNG among 83 isolates) [4], from Tripoli, Libya (35 7 % PPNG, 9 5 % CMRNG among 42 isolates) [5], and from Bahrain (45 % CMRNG among 91 non-PPNG) [12]. The gonococcal isolates tested in this study did, however, show susceptibility to alternative therapies such as ceftriaxone and spectinomycin.…”

Section: Discussionmentioning

confidence: 42%

“…As a consequence the prevalence of gonorrhoea in the Middle East is largely unknown and there is limited information on levels or types of antibiotic resistance [3][4][5]. Unlike many African and Asian countries, however, UAE and neighbouring countries have the facilities and antibiotics to control the spread of sexually transmitted infections, if used appropriately.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of gonococci isolated from men with urethritis in Dubai

Al-Hattawi

Ison

1996

Epidemiol. Infect.

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SUMMARYNeisseria gonorrhoeae were collected from men attending out-patient clinics in Dubai. The susceptibility to a range of therapeutic antibiotics and their auxotype and serotype was determined. The plasmid content of all penicillinase-producing strains was also analysed.Thirty-six strains of N. gonorrhoeae were isolated from specimens collected from 79 patients over a 24-day period. Of the 36 isolates, 9 (25 %) were penicillinase-producing N. gonorrhoeae (PPNG) and 15 (42 %) were chromosomally resistant N. gonorrhoeae (CMRNG). CMRNG exhibited higher levels of resistance to cefuroxime, chloramphenicol, tetracycline and erythromycin than PPNG. All isolates were susceptible to ceftriaxone and spectinomycin. Three (8 %) isolates showed reduced susceptibility (MIC, > 025 mg/l) to ciprofloxacin. Six isolates of PPNG carried the 4.4 MD and three the 3-2 MD penicillinase encoding plasmid. The total gonococcal population was phenotypically diverse, with 12 serovars, 6 auxotypes and 21 A/S classes. Gonorrhoea was found to be a major cause of urethritis in Dubai and the strains exhibited high levels of resistance to penicillin.

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Section: Discussionmentioning

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Characteristics of gonococci isolated from men with urethritis in Dubai

Al-Hattawi

Ison

1996

Epidemiol. Infect.

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“…Although living in a highly conservative community, the previous history of pelvic inflammatory disease with the accompanying symptoms of dysuria, dyspareunia, and vaginal discharge may suggest that our patient belonged to a high risk group for sexually transmitted diseases. In the Kingdom of Saudi Arabia the presence of penicillinase-producing N. gonorrhoeae has been recognised since 1981 [9]. Unlike our patient, the majority of patients infected with penicillinase-producing N. gonorrhoeae reported by Chowdhury et al [9] acquired the infections abroad.…”

Section: Discussioncontrasting

confidence: 47%

“…An inoculum of 105 colony forming units for both the control and test organisms was prepared as described before [9]. A rotary plate inoculator (Denley, Mast Laboratories Ltd., Liverpool, UK) was used to inoculate the centre of a chocolate blood agar plate with the test organism and the peripheral area with the control organism.…”

Section: Case Reportmentioning

confidence: 99%