Penicillium marneffei fungaemia in an allogeneic bone marrow transplant recipient

Woo, Patrick C. Y.; Lau, Susanna K. P.; Lau, Candy C. Y.; Chong, Ken T. K.; Hui, Wai-Ting; Wong, S.P.; Yuen, Kwok‐Yung

doi:10.1038/sj.bmt.1704895

Cited by 45 publications

(35 citation statements)

References 10 publications

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“…This and our previous studies showed that a higher proportion of HIV-infected patients with penicilliosis or cryptococcosis had cavitary lung lesions (17,18). As a result, penicilliosis should be included in the differential diagnosis of cavitary lung lesions for HIVinfected patients, and possibly for other immunocompromised patients, who have GM antigenemia in areas of endemicity (22).…”

Section: Discussionmentioning

confidence: 99%

Detection of Circulating Galactomannan in Serum Samples for Diagnosis ofPenicillium marneffeiInfection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Detection of Circulating Galactomannan in Serum Samples for Diagnosis ofPenicillium marneffeiInfection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus

et al. 2007

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“…(6,13,22). While sporadic cases of penicilliosis have been reported among non-HIV-infected Southeast Asians and travelers returning from the region (3,9,15,(23)(24)(25), concomitant or sequential infections with these intracellular pathogens in both apparently immunocompetent hosts and those with systemic lupus erythematosus (SLE) are extremely rare in the literature. In this study, we first describe in detail the clinical courses of 3 cases with autoantibody against IFN-␥ who suffered from recurrent culture-positive nontuberculous mycobacteriosis, penicilliosis, and nontyphoidal salmonellosis and then further elaborate on the findings of the immunological workup of these 3 patients and 5 others who also exhibited clinically significant opportunistic infections with the background of autoantibody against IFN-␥.…”

mentioning

confidence: 99%

Disseminated Penicilliosis, Recurrent Bacteremic Nontyphoidal Salmonellosis, and Burkholderiosis Associated with Acquired Immunodeficiency Due to Autoantibody against Gamma Interferon

Tang

Chan

Chen

et al. 2010

Clin Vaccine Immunol

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Acquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon.

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“…In recent decades, penicilliosis has emerged in HIV-infected and other immunocompromised patients in various countries (3)(4)(5)(6). Since the disease carries a high mortality rate and is associated with relapse, finding ways to improve diagnosis and treatment is crucial (7,8).…”

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confidence: 99%

In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin

Lau

Lam

et al. 2017

Antimicrob Agents Chemother

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We determined the susceptibilities of 57 Talaromyces marneffei strains to anidulafungin, itraconazole, voriconazole, and posaconazole with MICs of 2 to 8, 0.002 to 0.004, 0.016 to 0.063, and 0.001 to 0.002 g/ml by broth microdilution and Ͼ32, Յ0.002 to 0.008, Յ0.002 to 0.008, and Յ0.002 g/ml by Etest, respectively, at yeast phase; MICs at mycelial phase for anidulafungin and posaconazole were 1 to 2 and 0.004 to 0.063 g/ml, respectively. The results suggest promising activities of posaconazole. Etest can be used for testing of azoles against T. marneffei.

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Penicillium marneffei fungaemia in an allogeneic bone marrow transplant recipient

Cited by 45 publications

References 10 publications

Detection of Circulating Galactomannan in Serum Samples for Diagnosis ofPenicillium marneffeiInfection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus

Detection of Circulating Galactomannan in Serum Samples for Diagnosis ofPenicillium marneffeiInfection and Cryptococcosis among Patients Infected with Human Immunodeficiency Virus

Disseminated Penicilliosis, Recurrent Bacteremic Nontyphoidal Salmonellosis, and Burkholderiosis Associated with Acquired Immunodeficiency Due to Autoantibody against Gamma Interferon

In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin

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