One form of bizarre act from those suffering from Schizophrenia is pathological self-mutilating behavior. In general, there are three types of pathological selfmutilation. Among them, major self-mutilation (MSM) probably receives the most attention because of its rarity and severity. MSM is an uncommon act but often result in serious injury to the patient. It is almost always caused by psychotic illness. Some exotic examples of MSM include eye-enucleation, self-castration and self-amputation of limb. In this case report, we will discuss on a patient having schizophrenia with who performed self-amputation on his own penis using a knife after suffering from command auditory hallucinations.