Penile Calciphylaxis

Penile calciphylaxis, infrequent complication with bad prognosis: a case report

“…Penile calciphylaxis is a rare form of penile gangrene and is often a complication of end-stage renal disease (ESRD). 1 , 2 The underlying mechanism is thought to be related to vascular calcifications and fibrosis of the intima of medium and small arteries, leading to an obstructive vasculopathy and eventually, tissue necrosis. 1 Calciphylaxis is particularly rare because of the important vascular network of penis.…”

“… 1 , 2 The underlying mechanism is thought to be related to vascular calcifications and fibrosis of the intima of medium and small arteries, leading to an obstructive vasculopathy and eventually, tissue necrosis. 1 Calciphylaxis is particularly rare because of the important vascular network of penis. 3 , 4 , 5 Calciphylaxis is not only limited to patients with ESRD, it has been reported also in patients with earlier-stages-renal-disease, acute kidney injury, or prior receipt of kidney transplant.…”

“…The final occlusion can be supported by thrombosis endothelial injury. 1 , 3 Diagnosis is supported by biopsy or imaging. Penile biopsy has the high risk of inadequate wound healing, infection, and sepsis, but it might be necessary in the atypical presentation.…”

“…The global prevalence rate of calciphylaxis is estimated to be between 1 and 4.1% of patients with ESRD. 1 , 2 An increase in incidence, may be due to an actual increase or increased awareness of the disorder. It causes intense pain and tissue necrosis, prognosis is poor (<1 year).…”