Penile Cancer: Epidemiology and Treatment

Guimarães, Gustavo Cardoso; Rocha, Rafael Malagoli; Zéqui, Stênio de Cássio; Cunha, Isabela Werneck da; Soares, Fernando Augusto

doi:10.1007/s11912-011-0163-2

Cited by 44 publications

(40 citation statements)

References 63 publications

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“…Penile carcinoma (PeCa) is an aggressive and mutilating disease with high incidence in developing countries, with few therapeutic options available and high morbidity [1–3]. Several risk factors have been identified in PeCa etiology, including poor penile hygiene, phimosis and human papillomavirus (HPV) infection [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact

et al. 2017

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Penile carcinoma (PeCa) is an important public health issue in poor and developing countries, and has only recently been explored in terms of genetic and epigenetic studies. Integrative data analysis is a powerful method for the identification of molecular drivers involved in cancer development and progression. miRNA and mRNA expression profiles followed by integrative analysis were investigated in 23 PeCa and 12 non-neoplastic penile tissues (NPT). Expression levels of eight miRNAs and 10 mRNAs were evaluated in the same set of samples used for microarray and in a validation set of cases (PeCa = 36; NPT = 27). Eighty-one miRNAs and 2,697 mRNAs were identified as differentially expressed in PeCa. Integrative data analysis revealed 255 mRNAs potentially regulated by 68 miRNAs. Using RT-qPCR, eight miRNAs and nine transcripts were confirmed as altered in PeCa. We identified that MMP1, MMP12 and PPARG and hsa-miR-31-5p, hsa-miR-224-5p, and hsa-miR-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity. Higher MMP1 expression was detected as a better predictor of lymph node metastasis than the clinical-pathological data. In addition, PPARG and EGFR were highlighted as potential pathways for targeted therapy in PeCa. The analysis based on HPV positivity (7 of 23 cases) revealed five miRNA and 13 mRNA differentially expressed. Although in a limited number of cases, HPV positive PeCa presented less aggressive phenotype in comparison with negative cases. Overall, an integrative analysis using mRNA and miRNA profiles revealed markers related with tumor development and progression. Furthermore, MMP1 expression level was a predictive marker for lymph node metastasis in patients with PeCa.

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Section: Introductionmentioning

confidence: 99%

Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact

et al. 2017

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“…Squamous cell carcinoma is the most common penile malignancy. Risk factors for penile cancer include HPV infection, smoking, ultraviolet radiation and some pre‐existent conditions like chronic lichen sclerosus or phimosis …”

Section: Malignant Tumoursmentioning

confidence: 99%

Penile tumours: a review

Wollina

Verma²,

Tchernev

2014

Acad Dermatol Venereol

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Penile tumours are an important problem of male health affecting physical, mental and sexual health. Penile tumours can be subdivided into benign and malignant lesions. Their knowledge is important to prevent mutilating surgery in benign lesions. On the other hand, early recognition of malignancies is important for improved prognosis, and preservation of function. The most important tumour by epidemiology and prognosis is penile cancer. In contrast, malignant melanoma, sarcomas and lymphomas are rare. Clinical symptoms, histopathology and treatment options are discussed. Best possible treatment needs an interdisciplinary approach.

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“…In Brazil, Paraguai, Angola and India, the incidence of PC varies from 2.3 to 8.3 cases/100 000 men) (2,3). In Brazil annually around 1000 penile amputations are reported.…”

Section: Penile Cancer: the Importance Of Preventionmentioning

confidence: 99%

“…Phimosis and circumcision: phimosis (associated with the subjacent smegma and difficult hygiene of glans) is a known risk factor for PC (3,4,7,(14)(15)(16). Among Jewish men submitted to circumcision at birth, the incidence of PC is minimal (17).…”

Section: Is There a Possible Model Of Cancer Prevention?mentioning

confidence: 99%

Penile Cancer: the importance of Prevention

Zéqui

2013

Int. braz j urol.

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Penile Cancer: Epidemiology and Treatment

Cited by 44 publications

References 63 publications

Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact

Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact

Penile tumours: a review

Penile Cancer: the importance of Prevention

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