Penile cancer in younger men—A more aggressive disease?

O’Kelly, John; Browne, E; Daly, Pádraig; Keane, John; Shah, Nigam; Shilling, Christine; Cullen, I.M.

doi:10.1016/j.urolonc.2023.03.017

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Thus, our analysis is consistent with the previous findings, affirming that WLE could represent the best conservative approach for the treatment of localized primary PC to preserve sexual and erectile functions, without causing higher cancer recurrence rates. Interestingly, previous studies assessed how younger men diagnosed with PC showed worst outcomes in terms of nodal involvement and overall cancer-specific survival [22,23]. In this regard, our analysis showed that a younger age is associated with worse outcomes only in the setting of erectile function.…”

Section: Discussionmentioning

confidence: 63%

Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer

Cilio,

Tufano,

Pezone

et al. 2023

Current Oncology

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Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE) vs. glansectomy with urethral glanduloplasty. Methods: Complete data from 60 patients with PC were analyzed at our institution from 2017 to 2022. Patients were asked for personal habits and clinical features. PC was assessed with a clinical visit and imaging techniques. At the outpatient follow-up visit or phone call, all patients compiled the Changes in Sexual Function Questionnaire (CSFQ) and the International Index of Erectile Function in its short 5-item form (IIEF-5). Erectile function (EF) impairment was categorized using Cappelleri’s criteria. Results: Overall, 34 patients with PC confined to the glans (c ≤ T2N0) were included. Of those, 12 underwent WLE and 22 underwent glansectomy with urethral glanduloplasty. Using multivariable logistic regression, glansectomy (OR: 3.49) and diabetes (OR: 2.33) were associated with erectile disfunction (IEEF < 22). Meanwhile, using multivariable linear regression analysis, younger patients (Coeff: −2.41) and those that underwent glansectomy (Coeff: −7.5) had a higher risk of sexual function impairment, according to the CSFQ. Conclusions: Patients with PC ≤ T2N0 that underwent WLE have better outcomes in terms of sexual functioning than the patients who underwent glansectomy and uretheral gladuloplasty. Further research is needed to clarify the outcomes of penile-sparing surgery, to inform patients in pre-surgical counseling more comprehensively, and to meet their post-operative expectations more effectively.

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Section: Discussionmentioning

confidence: 63%