Penile‐preserving surgery for male distal urethral carcinoma

Smith, Yuko; Hadway, Paul; Ahmed, Shwan; Perry, Matthew; Corbishley, Catherine M.; Watkin, N.

doi:10.1111/j.1464-410x.2007.06901.x

Cited by 74 publications

(31 citation statements)

References 20 publications

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“…Smaller studies on the use of TGN have also been published, showing excellent local control and good cosmetic and functional results [2,3,6,8]. TGN has also been successfully used in the organ-sparing treatment of primary distal urethral cancer [27].…”

mentioning

confidence: 99%

Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres

Håkansson

Kirrander

Uvelius

et al. 2014

Scandinavian Journal of Urology

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Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres.Håkansson, Ulf; Kirrander, Peter; Uvelius, Bengt; Baseckas, Gediminas; Torbrand, Christian Link to publication Citation for published version (APA): Håkansson, U., Kirrander, P., Uvelius, B., Baseckas, G., & Torbrand, C. (2015). Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres. Scandinavian Journal of Urology, 49(2), 149-154. DOI: 10.3109/21681805.2014.955822 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Conclusions: GR and TGN seem to be oncologically safe procedures for treating carefully selected patients with penile cancer, and the functional and cosmetic results are promising.Based on our findings, we recommend that penile amputation should only be carried out in patients not suitable for organ-sparing reconstructive surgery.

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confidence: 99%

Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres

Håkansson

Kirrander

Uvelius

et al. 2014

Scandinavian Journal of Urology

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“…Chemotherapy combined with local radiotherapy has also been used as primary treatment for organ preservation in tumors of the male urethra, especially in moderately or poorly differentiated squamous cell carcinoma [20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Urethral carcinoma: critical view on contemporary consecutive series

et al. 2010

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Urethral carcinoma is a rare cancer of the urinary tract. Although most cases are of squamous cell carcinomas, there are several reports in the literature about transitional cell carcinoma and adenocarcinomas whose origin remains controversial. While the diagnosis of this condition is essentially clinical, magnetic resonance imaging (MRI) is the examination of choice for its staging, and a pathological confirmation is still necessary. There is no consensus on the treatment of these tumors because of its low incidence. The following therapeutic options are currently available: surgical resection (often for small and distal urethral tumors); radiotherapy and chemotherapy, for larger tumors, seeking a functional preservation of the penis, bladder and/or vagina; or a combination of these therapies thereof in case of more extensive tumors. The classic treatment involves surgery aiming loco-regional disease control, and continent urinary derivation provides satisfactory functional results in cases of radical urethrectomy. Much still needs to be learned about urethral cancer, and molecular diagnostics tools and therapeutic targets are promissory. The key to better understanding urethral cancer is the pooling of data from a wide range of sources including international consortia.

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“…[3][4][5] Distal urethral tumours are associated with precancerous lesions now known as penile intraepithelial neoplasia (PeIN) 6 and also with lichen sclerosus [previously known as balanitis xerotica obliterans (BXO)]. 7 In recent years, subspecialisation in urological surgery and the advent of penile-preserving surgery with reconstruction have led to penile and distal urethral tumours being referred to specialist surgical teams in some countries. In parts of the UK, the establishment of penile cancer supranetworks within the national cancer plan 8 has formalised this approach, with specialist penile cancer centres in the England and Wales treating between 25 and 130 new cases per year.…”

Section: Introductionmentioning

confidence: 99%