Peningkatan Laju Difusi Allisin dalam Sistem Fitosom Ekstrak Bawang Putih

Abstract

Garlic (Allium sativum L.) contains allicin, which has the biological activity of reducing blood sugar levels. The results of previous studies stated that the methanol extract of garlic was able to reduce blood sugar levels in mice with a dose of 400 mg/kg BW. Allicin permeability of extract can be increased by formulating it into the phytosome system. The objective of this study is to determine the eff ect of allicin loaded phytosome on the diff usion rate of allicin. Garlic extract phytosome was made using a thin layer hydration method which was then evaluated for its physicochemical properties which included testing of entrapment effi ciency, density, particle size, index polydispersion, and the zeta potential. Determination of the value of the diff usion rate of allicin in the extract and the phytosome system was carried out using a modifi ed diff usion cell for 420 minutes. The phytosome system formed has an entrapment effi ciency value of 64.8789 % with a density of 1.0051 g/mL, a particle size of 270 nm, the zeta potential of -32.55 mV, and a polydispersion index of 0.571. Diff usion rate testing indicates the phytosome system can increase the diff usion rate of allicin when compared to the diff usion rate of allicin in garlic extract.

Garlic Extract Phytosome: Preparation and Physical Stability

“…Other research has also shown that 246.1 nm of phytosome evodiamine played a significant role in the sustained release and enhancement of evodiamine's oral absorption efficiency [42]. In another study, phytosomes of garlic extract had a particle size of 270 nm, indicating that the rate of diffusion of allicin was greater than in the form of extract alone [43]. Based on the particle size, the phytosome of garlic extract was appropriate for oral and topical drug delivery.…”