(±)-Peniorthoesters A and B, Two Pairs of Novel Spiro-Orthoester en-antiomers With an Unusual 1,4,6-Trioxaspi-ro[4.5]decane-7-One Unit From Penicillium minioluteum

Liu, Xiaorui; Chen, Chunmei; Zheng, Yinyu; Zhang, Mi; Tong, Qingyi; Liu, Junjun; Zhou, Qun; Wang, Jianping; Luo, Zengwei; Zhu, Hucheng; Zhang, Yonghui

doi:10.3389/fchem.2018.00605

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…configs. were assigned by single-crystal X-ray diffraction analysis [226]. Compounds 481a/481b were characterized as a pair of cyclopentaisochromenone enantiomers from Alternaria sp.…”

Section: Nonalkaloidsmentioning

confidence: 99%

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Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Capon

et al. 2022

Molecules

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The knowledge that natural products (NPs) are potent and selective modulators of important biomacromolecules (e.g., DNA and proteins) has inspired some of the world’s most successful pharmaceuticals and agrochemicals. Notwithstanding these successes and despite a growing number of reports on naturally occurring pairs of enantiomers, this area of NP science still remains largely unexplored, consistent with the adage “If you don’t seek, you don’t find”. Statistically, a rapidly growing number of enantiomeric NPs have been reported in the last several years. The current review provides a comprehensive overview of recent records on natural enantiomers, with the aim of advancing awareness and providing a better understanding of the chemical diversity and biogenetic context, as well as the biological properties and therapeutic (drug discovery) potential, of enantiomeric NPs.

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“…configs. were assigned by single-crystal X-ray diffraction analysis [226]. Compounds 481a/481b were characterized as a pair of cyclopentaisochromenone enantiomers from Alternaria sp.…”

Section: Nonalkaloidsmentioning

confidence: 99%

“…In contrast, the levorotary enantiomer 407b was much more active (ca. 5 fold) than its antipodal enantiomer 407a in the LPS-induced NO release assay in BV-2 cells [130,132,226,265]. a positive controls.…”

Section: Anti-inflammationmentioning

confidence: 99%