Shifting demographics, rising costs of operations, a changing competitive landscape, reductions in state appropriations, pressures for accountability, and a widespread economic decline characterize the environment in which today's colleges and universities operate. This article examines some of the current responses to these challenges and outlines opportunities for advancing the mission of higher education in the 21st century. The topics covered include student centeredness, interdisciplinary research, access and affordability, technology, globalizing our universities, and service.