Pennyroyal Toxicity: Measurement of Toxic Metabolite Levels in Two Cases and Review of the Literature

Anderson, Ilene B.

doi:10.7326/0003-4819-124-8-199604150-00004

Cited by 234 publications

(132 citation statements)

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“…An autopsy in one of the children revealed hepatocellular necrosis, edematous hemorrhagic kidneys with ATN, left adrenal hemorrhage, and bilateral lung consolidation (69). Another report described a young woman who presented with oliguria and died within 48 h of multisystem organ failure and anoxic encephalopathy (71). Postmortem findings revealed acute proximal tubular degeneration.…”

Section: Hedeoma Pulegioides (Pennyroyal)mentioning

confidence: 99%

A Review of Dietary Supplement–Induced Renal Dysfunction

Gabardi

Munz²,

Ulbricht³

2007

Clinical Journal of the American Society of Nephrology

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Complementary and alternative medicine (CAM) is a multibillion-dollar industry. Almost half of the American population uses some form of CAM, with many using them in addition to prescription medications. Most patients fail to inform their health care providers of their CAM use, and physicians rarely inquire. Annually, thousands of dietary supplement-induced adverse events are reported to Poison Control Centers nationwide. CAM manufacturers are not responsible for proving safety and efficacy, because the Food and Drug Administration does not regulate them. However, concern exists surrounding the safety of CAM. A literature search using MEDLINE and EMBASE was undertaken to explore the impact of CAM on renal function. English-language studies and case reports were selected for inclusion but were limited to those that consisted of human subjects, both adult and pediatric. This review provides details on dietary supplements that have been associated with renal dysfunction and focuses on 17 dietary supplements that have been associated with direct renal injury, CAM-induced immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, and hepatorenal syndrome. It is concluded that it is imperative that use of dietary supplements be monitored closely in all patients. Health care practitioners must take an active role in identifying patients who are using CAM and provide appropriate patient education.

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Section: Hedeoma Pulegioides (Pennyroyal)mentioning

confidence: 99%

A Review of Dietary Supplement–Induced Renal Dysfunction

Gabardi

Munz²,

Ulbricht³

2007

Clinical Journal of the American Society of Nephrology

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“…On the other hand, fulminant hepatic necrosis in connection with its use has been repeatedly reported and the outcome has been lethal on several occasions. The primary constituent is pulegone besides various other monoterpenes characteristically encountered in mint species 89 but found in greater concentrations in pennyroyal. Hepatotoxic effects seem to be exerted by both pulegone producing oxidative stress and via pulegone's primary metabolite menthofuran, the latter being transformed to a hepatotoxin through cytochrome P450…”

Section: Miscellaneous Plantsmentioning

confidence: 99%

“…Direct depletion of glutathione by the formation of electrophilic metabolites seems to be the crucial step in pulegone toxicity, whereas menthofuran appears to act in a different manner 92 . Thus, replacement of sulphydryl groups by administering N-acetylcysteine, similar to treating paracetamol overdose, has recently been advocated as a rescue therapy in pennyroyal poisoning after immediate stomach cleansing 89 . The dosing, however, still remains empirical and recommendations are based on experimental data; an initial loading dose of 140 mg kg -1 body weight should be followed by a maintenance dose of 70 mg kg -1 every 4 hours.…”

Section: ±92mentioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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Objective: Hepatic impairment resulting from the use of conventional drugs is widely acknowledged, but there is less awareness of the potential hepatotoxicity of herbal preparations and other botanicals, many of which are believed to be harmless and are commonly used for self-medication without supervision. The aim of this paper is to examine the evidence for hepatotoxicity of botanicals and draw conclusions regarding their pathology, safety and applications. Design: Current literature on the hepatotoxicity of herbal drugs and other botanicals is reviewed. The aetiology, clinical picture and treatment of mushroom (Amanita) poisoning are described.

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“…Pulegone can be found in Mentha sp.pl., especially in M. pulegium essential oil, which also contains the bicyclic monoterpenes menthofuran and thujones (Anderson et al, 1996;Da Rocha et al, 2012;EFSA, 2012EFSA, , 2009EMA, 2016;Kristanc and Kreft, 2016a). Menthofuran is a hepatotoxin produced biosynthetically from pulegone (a compound with strong insecticidal activity) (Abdelli et al, 2016).…”

Section: Monoterpenes Phenylpropanoids and Prenylflavonoidsmentioning

confidence: 99%

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

Pinela

Ferreira

2017

Food and Chemical Toxicology

146

111

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A B S T R A C TWild edible plants (WEPs) are part of the cultural and genetic heritage of different regions of the world. In times of famine and scarcity, these sources of nutrients and health-promoting compounds have received high importance mainly in rural and suburban areas. Although currently underutilized, WEPs are still consumed traditionally by different communities and are gaining relevance in today's society. However, these foods lack recognition as significant contributors to the human diet in developed areas. This review describes the nutritional value of WEPs from the North-eastern region of Portugal and points out those containing potentially toxic compounds. Several retrieval strategies are presented with the aim of promoting the (re)use, production, commercialization and conservation of WEPs (wild harvested plants and crop wild relatives), and their importance for social, economic and agro-ecological development is highlighted.

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Pennyroyal Toxicity: Measurement of Toxic Metabolite Levels in Two Cases and Review of the Literature

Cited by 234 publications

References 0 publications

A Review of Dietary Supplement–Induced Renal Dysfunction

A Review of Dietary Supplement–Induced Renal Dysfunction

Hepatotoxicity of botanicals

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

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