Pentaammine(nitrogen)ruthenium(II) Salts and Other Ammines of Ruthenium

Allen, Annette D.; Bottomley, Frank; Harris, R. O.; Reinsalu, V. P.; Senoff, C. V.; Badger, David W.

doi:10.1002/9780470132432.ch1

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The complexes [RuCl(NH 3 ) 5 ]Cl 3 , [Ru(NH 3 ) 5 (H 2 O)](CF 3 SO 3 ) 3 ( 3 ), trans -[RuCl(NH 3 ) 4 (SO 2 )]Cl, and trans -[Ru(SO 4 )(NH 3 ) 4 (4-pic)]Cl were prepared from RuCl 3 ·3H 2 O as described in the literature. − …”

Section: Methodsmentioning

confidence: 99%

Secondary Coordination Sphere Effects in Ruthenium(III) Tetraammine Complexes: Role of the Coordinated Water Molecule

Souza¹,

Castellano²,

Telser

et al. 2015

Inorg. Chem.

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The complexes trans-[Ru(III)(NH3)4(4-pic)(H2O)](CF3SO3)3 (1) and [Ru(III)(NH3)5(4-pic)](CF3SO3)3 (2) were isolated and studied experimentally by electron paramagnetic resonance (EPR) and UV-vis spectroscopies, cyclic voltammetry, and X-ray crystallography and theoretically by ligand-field theory (LFT) and density functional theory (DFT) calculations. Complex 1 is reported in two different crystal forms, 1a (100 K) and 1b (room temperature). EPR and UV-vis spectroscopies suggest that aqua ligand interaction in this low-spin ruthenium(III) complex changes as a function of hydrogen bonding with solvent molecules. This explicit water solvent effect was explained theoretically by DFT calculations, which demonstrated the effect of rotation of the aqua ligand about the Npic-Ru-Oaq axis. The UV-vis spectrum of 1 shows in an aqueous acid solution a broad- and low-intensity absorption band around 28,500 cm(-1) (ε ≈ 500 M(-1) cm(-1)) that is assigned mainly to a charge-transfer (CT) transition from the equatorial ligands to the Ru β-4dxy orbital (β-LUMO) using DFT calculations. The electronic reflectance spectrum of 1 shows a broad and intense absorption band around 25,500 cm(-1) that is assigned to a CT transition from 4-picoline to the Ru β-4dxz orbital (β-LUMO) using DFT calculations. The t2g(5) set of orbitals had its energy splitting investigated by LFT. LFT analysis shows that a rhombic component arises from C2v symmetry by a simple π-bonding ligand (H2O in our case) twisting about the trans (C2) axis. This twist was manifested in the EPR spectra, which were recorded for 1 as a function of the solvent in comparison with [Ru(NH3)5(4-pic)](3+) and [Ru(NH3)5(H2O)](3+). Only 1 shows an evident change in the g-tensor values, wherein an increased rhombic component is correlated with a higher nucleophilicity (donor) solvent feature, as parametrized by the Abraham system.

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Section: Methodsmentioning

confidence: 99%

Secondary Coordination Sphere Effects in Ruthenium(III) Tetraammine Complexes: Role of the Coordinated Water Molecule

Souza¹,

Castellano²,

Telser

et al. 2015

Inorg. Chem.

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“…RuRed was purchased from Sigma-Aldrich (Cat. # R2751), and Ru265, Ru270 and Ru360', and other ruthenium complexes were synthesized as previously described (33,34,(59)(60)(61)(62)(63)(64)(65)(66). All compounds were dissolved in water.…”

Section: Bacterial Strains Media and Compoundsmentioning

confidence: 99%

Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa

Weber

Carfrae

Woods

et al. 2022

Preprint

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There is an urgent need to develop new antibiotics for the treatment of infections caused by drug-resistant Gram-negative bacteria. In particular, new and diverse chemical classes of antibiotics are needed, as most antibiotics in clinical development are derivatives of existing drugs. Despite a history of use as antimicrobials, metals and metal-based compounds have largely been overlooked as a source of new chemical matter for antibacterial drug discovery. In this work, we identify several ruthenium complexes, ruthenium red, Ru265, and Ru360’, that possess potent antibacterial activity against both laboratory and clinical isolates of Pseudomonas aeruginosa. Suppressors with increased resistance were sequenced and found to contain mutations in the mechanosensitive ion channel mscS-1 or the colRS two component system. The antibacterial activity of these compounds translated in vivo to Galleria mellonella larvae and mouse infection models. Finally, we identify strong synergy between these compounds and the antibiotic rifampicin, with a dose-sparing combination therapy showing efficacy in both infection models. Our findings provide clear evidence that these ruthenium complexes are effective antibacterial compounds against a critical priority pathogen and show promise for the development of future therapeutics.

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