Pentachlorophenol Intoxication: Report of a Fatal Case, with Comments on the Clinical Course and Pathologic Anatomy

Gray, Ronald E.; Gilliland, Richard D.; Smith, Edward E.; Lockard, Virginia G.; Hume, Arthur S.

doi:10.1080/00039896.1985.10545910

Cited by 21 publications

(13 citation statements)

References 7 publications

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“…6 Despite comprehensive knowledge on its kinetics, metabolism, and toxicology,7"11 the question of possible peripheral neurotoxic effects in man has not yet been adequately clarified. '2 In 1951 Baader and Bauer reported on neurological disorders in the context of a PCP intoxication.…”

mentioning

confidence: 99%

Pentachlorophenol and the peripheral nervous system: a longitudinal study in exposed workers.

Triebig

Csuzda

Krekeler

et al. 1987

Occupational and Environmental Medicine

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A longitudinal study was performed to examine whether chronic occupational exposure to pentachlorophenol (PCP) or its compounds causes measurable alterations in the conduction velocity in peripheral nerves as an "adverse effect." In total, the results of nerve conduction velocity (NCV) determinations in 1980 and 1984 in 10 subjects (7 men, 3 women) who had been exposed for an average of 16 years (range 4-24) were available. The concentrations of PCP in the air at the workplace varied between 0 3 and 180 yg/m3 and were thus below the maximum allowed concentration (MAK value) of 500 yg/m3. The biological monitoring carried out showed the following results: PCP in the serum: 38-1270 yg/l; PCP in the urine: 8-1224 pg/l. Compared with the upper normal limits (PCP in the serum 150 pg/l, PCP in the urine 60 pg/l), distinct internal exposure to PCP has resulted in some of the employees. Determinations of the NCV of motor and sensory nerve fibres (ulnar, median, peroneal, and sural nerve) were always in the normal range. A significant difference in the NCV for the period 1980-4 could not be detected. In addition, the correlation analyses did not show any hints of "dose-effect relations." It is concluded that occupational exposure to PCP over several years in the concentrations observed probably do not lead to any adverse effects on the peripheral nervous system. Pentachlorophenol (PCP) and its sodium salt are attaining increasing importance in industrial medicine and in environmental hygiene because of their wide distribution in preservatives and pesticides.Investigations on the toxicity of PCP were carried out more than 40 years ago.

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mentioning

confidence: 99%

Pentachlorophenol and the peripheral nervous system: a longitudinal study in exposed workers.

Triebig

Csuzda

Krekeler

et al. 1987

Occupational and Environmental Medicine

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“…In 1967, a cluster of cases of critical illness in a newborn nursery occurred as a result of the misuse of sodium pentachlorophenate as an anti-mildew agent in the hospital laundry; nine poisoning cases and two fatalities were reported [25]. This and other accounts of accidental occupational exposures provide ample toxicologic evidence of the risks from acute exposure to PCP [26,27].…”

Section: Pentachlorophenolmentioning

confidence: 99%

“…This effect is most pronounced in organ systems dependent on highperfusion and oxygen delivery, including the kidneys, heart, and CNS. On pathologic evaluation vacuolization of hepatocytes, proximal tubular cells, and myocardial tissue, as well as signs of mitochondrial injury have been shown in fatal cases involving neonates and adults [26,30]. Pentachlorophenol is also an inducer of cytochrome CYP3A [31], which could influence the metabolism of other drugs used in the critical care…”

Section: Pathophysiologymentioning

confidence: 99%

“…The clinical features attributed to PCP toxicity are best explained by the uncoupling of oxidative phosphorylation. Fever, tachypnea, tachycardia, and marked diaphoresis, all signs of a hypermetabolic state, are the most consistent findings [25][26][27]. Additional physical examination findings include hepatosplenomegaly in affected neonates [25].…”

Section: Clinical Presentationmentioning

confidence: 99%

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Fungicides

Lopez¹,

Sudakin²

2016

Critical Care Toxicology

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“…The commercial or technical grade of PCP is more toxic to aquatic organisms than its pure or analytical grade. The commercial or technical grade of PCP is heavily contaminated with compounds including chlorophenols, dioxins, dibenzofiirans, hexachlorobenzene and phenoxyphenols (5). PCP and its sodium salt, sodium pentachlorophenate are primarily used as wood preservatives and secondarily as a herbicides, insecticides or bactéricides.…”

Section: Introductionmentioning

confidence: 99%

Removal of Pentachlorophenol from Wastewater Using Peat

Viraraghavan¹,

Tanjore²

1994

Hazardous Waste and Hazardous Materials

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Pentachlorophenol (PCP), a versatile biocide has been extensively used in industry and agriculture. PCP has been designated as a priority organic pollutant by USEPA and its use in consumer products has been banned since 1984. Extensive use of PCP as a wood preservative has led to soil, surface water and groundwater pollution.Batch kinetic and isotherm studies were carried out at the Water Research Laboratory of the University of Regina, to determine the effectiveness of locally available horticultural peat in the adsorption of PCP from wastewater. Batch kinetic studies showed that 91% of PCP was removed from municipal wastewater spiked with approximately 1 mg/L of PCP, with an equilibrium time of five hours. An optimum pH range of 3.0 -3.5 was found to give maximum PCP removals.

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Pentachlorophenol Intoxication: Report of a Fatal Case, with Comments on the Clinical Course and Pathologic Anatomy

Cited by 21 publications

References 7 publications

Pentachlorophenol and the peripheral nervous system: a longitudinal study in exposed workers.

Pentachlorophenol and the peripheral nervous system: a longitudinal study in exposed workers.

Fungicides

Removal of Pentachlorophenol from Wastewater Using Peat

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