Pentacoordinated Cu(II)/Zn(II) complexes bearing macrocyclic skeleton: synthesis, spectroscopic and molecular structure optimization studies

A rationally designed metal-binding helical peptoid for selective recognition processes

“…For this purpose, we chose 2,2′:6′,2′′-terpyridine (Terpy) as the second ligand, resulting in the design of peptoid Helix HQT i + 3 (Scheme 1). We assumed that this peptoid would have high affinity and high selectivity for Cu 2+ via intramolecular binding to both HQ and Terpy because such coordination can lead to a square pyramid geometry, which can be stabilized by Cu 2+ but not by neighboring metal ions, such as Zn 2+ , Fe 3+ , Co 2+ , Ni 2+ and Mn 2+ , that can also bind these ligands 12. Moreover, as this peptoid includes two distinct binding sites, we anticipated that intermolecular coordination of two different metal ions would be also possible, probably under modified reaction conditions.…”

“…We assumed that this peptoid would have high affinity and high selectivity for Cu 2+ via intramolecular binding to both HQ and Terpy because such coordination can lead to a square pyramid geometry, which can be stabilized by Cu 2+ but not by neighboring metal ions, such as Zn 2+ , Fe 3+ , Co 2+ , Ni 2+ and Mn 2+ , that can also bind these ligands. 12 Moreover, as this peptoid includes two distinct binding sites, we anticipated that intermolecular coordination of two different metal ions would be also possible, probably under modified reaction conditions. Such binding will lead to the production of unique hetero-bimetallic peptoid duplexes in which Cu 2+ is bound to two HQ ligands, stabilizing a tetragonal geometry, and a second metal ion, e.g.…”

A Pure Polyproline Type I‐like Peptoid Helix by Metal Coordination

“…[18] HQ is as trong chelator for divalent metal ions such as Co 2 + ,C u 2 + ,a nd Zn 2 + . [19] All peptoids consist of seven monomers and bear two HQ groups incorporated at the 2nd and 5th positions. These positions were chosen in accordance Figure 1.…”