2009
DOI: 10.1055/s-0029-1186102
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Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy

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Cited by 435 publications
(334 citation statements)
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“…Triterpenoids are the metabolites of isopentenyl phosphate oligomers and constitute the largest group of phytochemicals with more than 20 000 known compounds available in nature [56] . A large number of tri-terpenoids have been shown to suppress the growth of a variety of cancer cells without exerting any toxicity in normal cells [57][58][59] . Numerous preclinical efficacy studies have provided extensive evidence that both naturally occurring and synthetic derivatives of triterpenoids possess chemopreventive and therapeutic effects against colon, breast, prostate and skin cancer [56,[60][61][62][63][64] .…”
Section: Terpenoidsmentioning
confidence: 99%
“…Triterpenoids are the metabolites of isopentenyl phosphate oligomers and constitute the largest group of phytochemicals with more than 20 000 known compounds available in nature [56] . A large number of tri-terpenoids have been shown to suppress the growth of a variety of cancer cells without exerting any toxicity in normal cells [57][58][59] . Numerous preclinical efficacy studies have provided extensive evidence that both naturally occurring and synthetic derivatives of triterpenoids possess chemopreventive and therapeutic effects against colon, breast, prostate and skin cancer [56,[60][61][62][63][64] .…”
Section: Terpenoidsmentioning
confidence: 99%
“…63 subjects (4 patients, 35 healthy volunteers, and 24 adults) received a singledose of ursolic acid liposomes (11,22,37,56,74,98, and 130 mg/ m 2 ) administered as a 4-h intravenous infusion. The clinical data reported for the first time that liposomal ursolic acid had manageable toxicities with MTD of 98 mg/m 2 .…”
Section: Human Clinical Trials With Ursolic Acidmentioning
confidence: 99%
“…Ursolic acid may occur as free acid or as aglycone of saponins. Recent evidences have supported the beneficial effects of ursolic acid in a variety of human diseases, including various types of inflammation-driven cancers [11]. Anti-inflammatory and antiproliferative, proapoptotic, antimetastatic and antiangiogenic potential of ursolic acid have been reported in both in vitro and in vivo models of cancer [7].…”
Section: Introductionmentioning
confidence: 96%
“…The pentacyclic triterpenes are five-ring derivatives of dammarane having a chairchair-chair-boat configuration and can be classified into lupane, oleanane, ursane or glycyrrhizic acid groups, and are one group of promising secondary plant metabolites [113].…”
Section: Gap Junction Channel Inhibitors (Fig 2)mentioning
confidence: 99%