Pentacyclic Triterpenoids, Phytosteroids and Fatty Acid Isolated from the Stem-bark of Cola lateritia K. Schum. (Sterculiaceae) of Cameroon origin; Evaluation of Their Antibacterial Activity

Kamdem, Michael Hermann Kengne; Ojo, Olusesan; Kemkuignou, Blondelle Matio; Talla, Rostan Mangoua; Fonkui, Thierry Y.; Silihe, Kevine Kamga; Tata, Charlotte Mungho; Fotsing, Marthe Carine Djuidje; Mmutlane, Edwin M.; Ndinteh, Derek Tantoh

doi:10.1016/j.arabjc.2021.103506

Cited by 10 publications

(2 citation statements)

References 17 publications

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“…Phosphate moieties such as phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, or phosphatidylinositol are found in the sn-3 (lower) position. Also, [20] isolated heptadecanoic acid, a saturated fatty acid, five pentacyclic triterpenoids, and two phytosteroids from the stem-bark of Cola lateritia K. Schum. (Sterculiaceae) from Cameroon, showing the presence of an uncommon fatty acid in the Cola K. Schum family.…”

Section: Resultsmentioning

confidence: 99%

Fatty Acid Composition of Red Monkey Kola (Cola Millenii K. Schum) Fruit and Bark Obtained in Gariki, Enugu State, Nigeria

Chinenye¹,

Ifeanyi²,

Maryrose³

et al. 2022

AJAC

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Many studies have focused on the phytochemical, antioxidant, and mineral content of red monkey kola (Cola Millenii K. Schum), but there is little or no information on the fatty acid composition of this unique and underutilized plant, which is widely consumed in Africa. With this in mind, the fatty acid composition of the red monkey kola fruit and bark obtained in Gariki, Enugu State, was determined in order to determine the type of fatty acid present in the plant as well as its benefits for its consumers. The GCMS chromatogram data revealed the presence of five fatty acid compounds in the fruit sample, including oleic acid (8.094%), stearic acid (0.297%), petroselinic acid (1.237%), palmitic acid (2.290%), and cis-10-nonadeconic acid (0.183%). The bark sample contained cis-10-nonadecenoic acid (8.946%), palmitic acid (2.911%), petroselinic acid (1.881%), stearic acid (0.539%), and 18-nonadecenoic acid (0.366%). Oleic acid was found to be only present in the fruit sample, as the presence of this omega 9 fatty acid conferred numerous health benefits to the consumers. Other unsaturated acids such as petroselinic acid and saturated fatty acids like stearic acid are important compounds used as anti-inflammatory, anti-aging and as a supporting substitute for trans-fat in vegetable oils.

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Section: Resultsmentioning

confidence: 99%

Fatty Acid Composition of Red Monkey Kola (Cola Millenii K. Schum) Fruit and Bark Obtained in Gariki, Enugu State, Nigeria

Chinenye¹,

Ifeanyi²,

Maryrose³

et al. 2022

AJAC

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“…Friedelin has been extensively researched for its potential health advantages and various biological properties, such as its ability to inhibit the growth of microorganisms. Friedelin extracted from Pterocarpus erinaceous [25], Azima tetracantha [24], Jatropha tanjorensis [26], Calophyllum inophyllum, Maytenus undata [74], Calophyllum brasiliense [73], Garcinia smeathmannii [72], and Cola lateritia K. Schum [116] have been reported to have antimicrobial properties against bacterial and fungal pathogens, as shown in Table 4. The antibacterial and resistance-modifying activities of friedelin isolated from the methanol extract of Paullinia pinnata L. roots were evaluated in vitro against Staphylococcus aureus strains SA1199B, RN4220, and XU212.…”

Section: Antimicrobial and Antiparasitic Activitymentioning

confidence: 99%

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact

Singh,

Shrivastava,

Mishra

et al. 2023

Molecules

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Pharmaceutical companies are investigating more source matrices for natural bioactive chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant species from different families as well as mosses and lichen. The fundamental compounds of these friedelane triterpenoids are abundantly found in cork tissues and leaf materials of diverse plant genera such as Celastraceae, Asteraceae, Fabaceae, and Myrtaceae. They possess many pharmacological effects, including anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Friedelin also has an anti-insect effect and the ability to alter the soil microbial ecology, making it vital to agriculture. Ultrasound, microwave, supercritical fluid, ionic liquid, and acid hydrolysis extract friedelin with reduced environmental impact. Recently, the high demand for friedelin has led to the development of CRISPR/Cas9 technology and gene overexpression plasmids to produce friedelin using genetically engineered yeast. Friedelin with low cytotoxicity to normal cells can be the best phytochemical for the drug of choice. The review summarizes the structural interpretation, biosynthesis, physicochemical properties, quantification, and various forms of pharmacological significance.

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Cytotoxic and antibacterial activities of compounds isolated from the fruits and stem-bark of Tetrapleura tetraptera (Schumach. & Thonn.) Taub. (Fabaceae)

et al. 2022

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Pentacyclic Triterpenoids, Phytosteroids and Fatty Acid Isolated from the Stem-bark of Cola lateritia K. Schum. (Sterculiaceae) of Cameroon origin; Evaluation of Their Antibacterial Activity

Cited by 10 publications

References 17 publications

Fatty Acid Composition of Red Monkey Kola (Cola Millenii K. Schum) Fruit and Bark Obtained in Gariki, Enugu State, Nigeria

Fatty Acid Composition of Red Monkey Kola (Cola Millenii K. Schum) Fruit and Bark Obtained in Gariki, Enugu State, Nigeria

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact

Cytotoxic and antibacterial activities of compounds isolated from the fruits and stem-bark of Tetrapleura tetraptera (Schumach. & Thonn.) Taub. (Fabaceae)

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