Pentalinonsterol, a Phytosterol from Pentalinon andrieuxii, is Immunomodulatory through Phospholipase A2 in Macrophages toward its Antileishmanial Action

Shelton, Andrew; Kotha, Sainath R.; Gurney, Travis O.; Gupta, Gaurav; Hund, Thomas J.; Fuchs, James R.; Kinghorn, A. Douglas; Satoskar, Abhay R.; Parinandi, Narasimham L.

doi:10.1007/s12013-021-01030-8

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…The reduction effects of plant stanols on the serum levels of TNF-α were observed in healthy subjects and patients with inflammatory disorders, but only inconsistently [ 152 , 153 ]. Pentalinonsterol (cholest-4,20,24-trien-3-one), a sterol from Pentalinon andrieuxii , enhanced phospholipase A2 (PLA2) activity, and TNF-α production in BMDMs [ 154 ]. Thus, not all plant sterols appear to be anti-inflammatory compounds.…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Yanagisawa

Asai

et al. 2022

IJMS

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Cholesterol and its oxidized forms, oxysterols, are ingested from foods and are synthesized de novo. Cholesterol and oxysterols influence molecular and cellular events and subsequent biological responses of immune cells. The amount of dietary cholesterol influence on the levels of LDL cholesterol and blood oxysterols plays a significant role in the induction of pro-inflammatory state in immune cells, leading to inflammatory disorders, including cardiovascular disease. Cholesterol and oxysterols synthesized de novo in immune cells and stroma cells are involved in immune homeostasis, which may also be influenced by an excess intake of dietary cholesterol. Dietary compounds such as β-glucan, plant sterols/stanols, omega-3 lipids, polyphenols, and soy proteins, could lower blood cholesterol levels by interfering with cholesterol absorption and metabolism. Such dietary compounds also have potential to exert immune modulation through diverse mechanisms. This review addresses current knowledge about the impact of dietary-derived and de novo synthesized cholesterol and oxysterols on the immune system. Possible immunomodulatory mechanisms elicited by cholesterol-lowering dietary compounds are also discussed.

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Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Yanagisawa

Asai

et al. 2022

IJMS

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“…b.f. Hansen & Wunderlin is an herbaceous Mexican plant belonging to the Apocynaceae family (Morales 2009); the roots of the plant are used by Mayan healers to treat cutaneous leishmaniosis (Chan-Bacab et al 2003, Lezama-Dávila et al 2014) and its phytochemical knowledge includes production of secondary metabolites such as coumarins, sterols and terpenoids (Yam-Puc et al 2009, Pan et al 2012. The terpenoids reportedly produced by P. andrieuxii include betulinic acid, a triterpene with several biological properties such as antiparasitic, antiviral, and antileukemic properties (Lezama-Dávila et al 2014, Gupta et al 2015, Meira et al 2016, Varikuti et al 2022, and urechitol A, a tri-nor-sesquiterpenoid with an unusual carbon skeleton of unknown biosynthetic origin (Yam-Puc et al 2009). A recent investigation into the accumulation dynamics of terpenoids in wild plants of P. andrieuxii showed that while betulinic acid accumulates in plant leaves at all stages of plant development, with no apparent relationship to plant ontogeny, maximum production of urechitol A occurs in plants in the adult stage and is restricted to the root tissue (Hiebert-Giesbrecht et al 2016).…”

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confidence: 99%

Influence of the flowering stage in the production of urechitol A in Agrobacterium rhizogenes-transformed plants of Pentalinon andrieuxii

Pires-Moreira,

Chan-Poot,

Avilés-Berzunza

et al. 2024

Bot. Sci.

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Background: Pentalinon andrieuxii, is a medicinal plant used in Mayan folk medicine against leishmaniosis. It is an important source of terpenoids whose biosynthesis has been reported to be influenced by the ontogeny of the plant. Hypotheses: Flowering positively influences the production of urechitol A in Pentalinon andrieuxii. Studied species: Pentalinon andrieuxii (Müll. Arg.) B.F. Hansen & Wunderlin (Apocynaceae) Study site and dates: Mérida, Yucatán, Mexico, 2019 and 2020. Methods: Flowering was induced by exposing plants to temperatures above 32 °C. Plant tissue samples were collected before flowering induction and at full bloom and extracted with methanol. Analyses of the dichloromethane-soluble fraction of the crude extract by Gas Chromatography-Mass Spectrometry allowed the detection and quantification of urechitol A. Results: Flowering stage of P. andrieuxii has a positive influence on the production of urechitol A in the root of the plant, with the contents of the tri-nor-sesquiterpene increasing from a minimum of 43 to a maximum of 91 times during the flowering stage of plants, both transformed and wild type. Conclusions: P. andrieuxii perceives high temperatures as an important environmental cue to flower; flowering positively influences the production of urechitol A in the roots of the plant; production of the tri-nor-sesquiterpene is controlled by the plant.

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Parasite phospholipases A, signaling events, and contribution to pathogenesis

Belaunzarán

2023

Phospholipases in Physiology and Pathology

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Pentalinonsterol, a Phytosterol from Pentalinon andrieuxii, is Immunomodulatory through Phospholipase A2 in Macrophages toward its Antileishmanial Action

Cited by 4 publications

References 52 publications

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Influence of the flowering stage in the production of urechitol A in Agrobacterium rhizogenes-transformed plants of Pentalinon andrieuxii

Parasite phospholipases A, signaling events, and contribution to pathogenesis

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