Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study

Brasileiro, José Lacerda; Ramalho, Rondon Tosta; Aydos, Ricardo Dutra; Silva, Iandara Schettert; Takita, Luis Carlos; Marks, Guido; Assis, Peterson Vieira de

doi:10.1590/s0102-86502015002000005

Cited by 3 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More recent studies on animal small intestine and liver tissues have suggested a beneficial effect of PGE1 on ischemia/reperfusion injury …”

mentioning

confidence: 99%

See 1 more Smart Citation

Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Bharathan¹,

Chandran²,

Gopalakrishnan³

et al. 2016

Liver Transpl

View full text Add to dashboard Cite

The role of prostaglandin E1 (PGE1) infusion in improving early graft function has not been well defined, especially in the scenario of living donor liver transplantation (LDLT). We designed a randomized, double-blind, placebo-controlled trial to evaluate the role of perioperative PGE1 infusion in LDLT. Patients in the study arm received PGE1 (alprostadil) at the rate of 0.25 μg/kg/hour, starting at 1 hour after portal venous reperfusion, and continued for 96 hours. The primary endpoint was early allograft dysfunction (EAD). We analyzed multiple secondary endpoints including postoperative liver function and renal function parameters, acute kidney injury (AKI), hepatic artery thrombosis (HAT), postoperative bleeding, overall mortality, and posttransplant hospital stay. The incidence of EAD was lower in the PGE1 arm, although the difference did not reach statistical significance (22.4% versus 36%; P = 0.21). Among the secondary endpoints, the incidence of AKI was significantly lower in the PGE1 arm (8.2% versus 28%; P = 0.02), as were the peak and mean postoperative creatinine levels. The need for renal replacement therapy was similar between the 2 groups. Among the postoperative graft function parameters, postoperative alanine aminotransferase level was significantly lower in the PGE1 arm (P = 0.04), whereas the remaining parameters including serum bilirubin, aspartate aminotransferase, and international normalized ratio were similar between the 2 arms. There was no difference in the incidence of HAT and postoperative bleeding, in-hospital mortality, and posttransplant hospital stay between the 2 arms. Perioperative PGE1 infusion reduces the incidence of posttransplant renal dysfunction in patients undergoing LDLT. Liver Transplantation 22 1067-1074 2016 AASLD.

show abstract

“…More recent studies on animal small intestine and liver tissues have suggested a beneficial effect of PGE1 on ischemia/reperfusion injury …”

mentioning

confidence: 99%

“…(13) More recent studies on animal small intestine and liver tissues have suggested a beneficial effect of PGE1 on ischemia/reperfusion injury. (14)(15)(16) The use of PGE1 in the treatment of established PNF was first reported by Greig et al in 1989. (17) Two randomized trials studied the role of perioperative PGE1 infusion in DDLT recipients.…”

mentioning

confidence: 99%

Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Bharathan¹,

Chandran²,

Gopalakrishnan³

et al. 2016

Liver Transpl

View full text Add to dashboard Cite

show abstract

“…Рядом ученых [34,35] было доказано поло-жительное действие пентоксифиллина и проста-гландина E1 на тонкий кишечник у крыс после ишемии-реперфузии. Иммуногистохимические результаты продемонстрировали достоверное увеличение анти-FAS лиганда (фактора некро-за) в клетках эпителия слизистой кишечника, что позволяет этим клеткам быстро возобнов-лять эпителиальную выстилку.…”

Section: коррекция метаболических нарушений и регенерацииunclassified

Diagnosis and Treatment of Syndrome of Intestinal Insufficiency in Acute Bleeding from Upper Gastrointestinal Tract

Климович¹,

Maskin²,

Abpamov³

2017

Novosti Khirurgii

View full text Add to dashboard Cite

Острая массивная кровопотеря из гастродуоденальной зоны приводит к развитию синдрома кишечной недостаточности (СКН) вследствие ишемических и последующих реперфузионных повреждений стенки кишечника. Нарушение барьерных функций стенки кишки обусловливает массивное поступление внутрикишечных токсинов в портальный кровоток и кишечный лимфа-тический коллектор и служит триггером формирования полиорганной недостаточности. Вслед-ствие чего остро возникают вопросы ранней диагностики развития СКН, которые в настоящее время представляют широкую гамму инвазивных биохимических исследований, изучение мио-электрических параметров и данных сонографии. Однако учитывая сложный, разносторонний характер патогенеза кишечной недостаточности, чрезвычайно трудно выделить из них наиболее информативные. На сегодняшний день в клинической практике установленной стратегии лече-ния СКН при желудочно-кишечных кровотечениях (ЖКК) нет. Основные направления терапии СКН ограничиваются интраинтестинальной детоксикацией и коррекцией окислительного стресса. Это объясняет большое количество экспериментальных работ, в которых при моделировании геморрагической гипотензии и ишемически-реперфузионных поражений кишечника, изучаются возможности поддержки его секреторной и кинетической функций, коррекции метаболических нарушений и регенерирующих механизмов, усиления антиоксидантных и противовоспалительных способностей. Тем не менее, несмотря на большой арсенал экспериментальных и клинических исследований, вопросы ранней диагностики и этиопатогенетического лечения СКН далеки от разрешения и требуют дальнейшего изучения.Ключевые слова: синдром кишечной недостаточности, желудочно-кишечное кровотечение, ишемия-репер-фузия, диагностика кишечной недостаточности, лечение кишечной недостаточности, стенка кишки Acute massive bleeding from the gastroduodenal zone leads to the development of the syndrome of intestinal insufficiency (SII), due to ischemia/reperfusion injury of the intestinal wall. Violation of the barrier functions of the intestinal wall causes a massive inflow of the toxins from the intestine to the portal circulation and intestinal lymphatic collector that triggers multiple organ failure. As a result the issue of early diagnosis of the SII arises urgently, which currently represent a wide range of invasive biochemical studies, studying of myoelectric parameters and sonography data. However, taking into consideration the complicated, multilateral nature of the pathogenesis of intestinal insufficiency, it is extremely difficult to differentiate the most informative one. At a result, in the clinical practice there is no established strategy of SII treatment in the gastrointestinal bleeding (GIB). The main tendencies of SII therapy are limited by intraintestinal detoxification and correction of oxidative stress. This explains a large number of experimental studies in which using the modeling of hemorrhagic hypotension and intestinal ischemia/reperfusion lesions, the possibilities of supporting its secretory and kinetic functions, the correction of metabo...

show abstract

Potential benefits of pentoxifylline on wound healing

Ahmadi

Khalili

2015

Expert Review of Clinical Pharmacology

View full text Add to dashboard Cite

In this review, potential benefits of pentoxifylline (PTX) on wound healing have been evaluated. All available experimental and clinical studies examined effects of PTX on wound healing have been included. No time limitation was considered and all studies up to writing the manuscript were included. Administration of oral or parenteral PTX showed beneficial effects on the healing of colorectal anastomosis, post burn scar, radiation-induced skin/soft tissue injury, venous ulcers, recurrent aphthous stomatitis and cutaneous/mucocutaneous leishmaniasis. Data regarding effect of PTX on skin flap survival are conflicting. Only few evidences support promising effects of PTX in pressure ulcer, skin developing injury and burn.

show abstract

Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study

Cited by 3 publications

References 19 publications

Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Diagnosis and Treatment of Syndrome of Intestinal Insufficiency in Acute Bleeding from Upper Gastrointestinal Tract

Potential benefits of pentoxifylline on wound healing

Contact Info

Product

Resources

About