Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie's Disease. Results of a Controlled Study

Abstract

Objective: The study was made mainly to investigate the possible benefits of multimodal treatment using Pentoxifylline (PTX) with other antioxidants, in patients with PD enrolled for a conservative medical management. Methods: We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection. Two groups (A and B) were totally composed by 160 PD patients (80 patients for each group): Group A=PTX injection (penile and peri-lesional) 100 mg, every two weeks for six months + PTX 400 mg /oral/ twice daily + propolis 600 mg / oral / daily + blueberries 160 mg /oral/ daily + Vitamin E 600 mg / oral / daily + topical Diclofenac sodium 4% gel / twice a day, for a period of 6 months. Group B=the same therapy of group A but without PTX penile injection. Patients who refused treatment, for various reasons, were included in the control group=Group C (80 patients). Results: In groups A and B after 6 months of treatment a reduction of penile plaque volume of 50.3% and 25.9% respectively was observed, while in group C a mean increase in plaque volume of 131% was observed. Furthermore, in groups A and B, the mean curvature decrease was -11.07° and -4.4° respectively, while in group C a mean increase of curvature =+14.09° was observed. Conclusion: Our results showed that multimodal treatment with PTX associated with antioxidants and topical Diclofenac is significantly effective in treating PD. Treatment outcomes obtained in the treatment-group A are statistically more significant than those achieved in group B. Pentoxifylline is more effective when the treatment program includes both routes of administration: oral + perilesional injection.

Efficacy and safety evaluation of pentoxifylline associated with other antioxidants in medical treatment of Peyronie's disease: a case-control study

“… 38 – 40 In this study, we decided to continue our positive experience with multimodal PD therapy, and thus, for the second time with a larger sample, we found an association between oral antioxidants and local perilesional injections, replacing verapamil with PTX, and administering it both orally and via injection. 33 The reason behind this choice is that, in addition to its strong antioxidant effect, PTX also has antifibrogenic activity. 45 – 48 …”

A Review on Marine Algae and Its Applications

“…Chlamydomonas reinhardtii, the green algae model produces many therapeutic proteins for human and animals including full-length human antibodies [65]. Production of bioactive compounds by green algae is a fortunate thing to pharmaceutical research [66][67][68][69][70]. The biomass of Nostoc is being used as a dietary supplement composing rich protein, lipids, and fatty acid content.…”

Buccal mucosa is a promising graft in Peyronie’s disease surgery. Our experience and a brief literature review on autologous grafting materials

“…At the present, there is no cure for PD. The medical best approach seems to be "multimodal therapy" that is able to achieve greater results than any single drug alone tested in scientific literature (5)(6). Surgery represent yet the gold standard of treatment.…”