Pentoxifylline in dermatology

Balazic, Eliza; Axler, Eden; Konisky, Hailey; Khanna, Urmi; Kobets, Kseniya

doi:10.1111/jocd.15445

Cited by 4 publications

(4 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to our findings, the concomitant use of clobetasol plus PTX was also an interesting combination with better outcomes than clobetasol in monotherapy. The use of PTX in dermatologic conditions is growing [29]. This drug is a phosphodiesterase inhibitor that lowers the platelet aggregation and augments the production of eicosanoid, with antioxidant and vasodilator properties [30].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris

Husein-ElAhmed,

Husein-ElAhmed

2023

Dermatology

View full text Add to dashboard Cite

BACKGROUND: Lichen planopilaris (LPP) is a primary chronic lymphocytic cutaneous disorder that selectively destroys the hair follicles, resulting in a scarring alopecia. Unfortunately, current available treatments are not fully effective to stop hair loss, and the level of evidence for medical interventions is weak. METHODS: A systematic review and meta-analysis was performed including randomized trials that report the outcomes of lichen planopilaris activity index (LPPAI). These articles were pooled and a network meta-analysis (NAM) was conducted. RESULTS: A total of seven studies was identified and included in meta-analysis, comprising 251 LPP patients. The NMA showed the mean difference in LLPAI was significantly superior with the combination of clobetasol plus N-acetylcysteine (mean difference: -2.0, 95%CI=-3.43- -0.51) and the combination of clobetasol plus pentoxyfilline (mean difference: -1.62, 95%CI=-3.0- -0.25) compared to the treatment of reference (clobetasol). The NMA showed cyclosporine (mean difference: 2.05 95%CI= 0.68-3.49), methotrexate (mean difference: 1.95 95%CI= 1.23-3.17), the combination of methotrexate plus prednisolone (mean difference: 1.56 95%CI= 0.25-2.96) were significantly worse than hydroxychloroquine according to the differences in LLPAI. CONCLUSION: This work is the first NMA in LPP and hence, it can be helpful serving as an initial step towards better evidence-based decisions in the treatment of this challenging condition. We propose a triple combined approach consisting of topical clobetasol, hydroxychloroquine and N-acetylcysteine as resulted in the most effective approach. Considering the poor outcomes observed with pioglitazone, mycophenolate mofetil, and cyclosporine, it is advisable to contemplate the use of these medications in patients who have not responded adequately to more efficacious alternatives.

show abstract

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris

Husein-ElAhmed,

Husein-ElAhmed

2023

Dermatology

View full text Add to dashboard Cite

show abstract

“…Hence, this good response could result from pentoxifylline, a methyl-xanthine derivative used in various dermatological diseases, most notably varicosity. 14 We hypothesized that, apart from its hemorheological effects in varicosity, pentoxifylline plays a role in the treatment of PPPD by; (1) inhibition of interleukin (IL)-1, IL-6, and tumor necrosis factor-α; (2) suppression of neutrophils, T cells, and B cells; (3) decreased expression of endothelial adhesion molecules; and (4) inhibition of fibroblast biosynthesis. 14 This finding may lead to the hypothesis that leg varicosity or chronic venous insufficiency may involve in the mechanism of this condition, guiding further research for investigating the pathogenesis of PPPD.…”

Section: Discussionmentioning

confidence: 99%

“… 14 We hypothesized that, apart from its hemorheological effects in varicosity, pentoxifylline plays a role in the treatment of PPPD by; (1) inhibition of interleukin (IL)-1, IL-6, and tumor necrosis factor-α; (2) suppression of neutrophils, T cells, and B cells; (3) decreased expression of endothelial adhesion molecules; and (4) inhibition of fibroblast biosynthesis. 14 This finding may lead to the hypothesis that leg varicosity or chronic venous insufficiency may involve in the mechanism of this condition, guiding further research for investigating the pathogenesis of PPPD. Nevertheless, this hypothesis may be limited by the fact that venous stasis in our patient has yet to be appropriately evaluated.…”

Section: Discussionmentioning

confidence: 99%

Pretibial Pruritic Papular Dermatitis: A Case Report and Emphasis on Effective Treatment with Pentoxifylline

Sakpuwadol¹,

Harnchoowong²,

Suchonwanit³

2023

CCID

View full text Add to dashboard Cite

Pretibial pruritic papular dermatitis (PPPD) is a distinctive skin disorder in response to persistent pretibial manipulation. Clinically, it manifests as multiple discrete, pruritic, flesh-colored-to-erythematous papules and plaques confined to the pretibial area. The histological hallmark of PPPD comprises irregular epidermal psoriasiform hyperplasia with parakeratosis and spongiosis, dermal fibrosis, and lymphohistiocytic infiltration. Due to its rarity and underrecognition, the prevalence and standard treatment of the disease have yet to be well elucidated. Here, we present a case of PPPD in a 60-year-old female presenting with numerous pruritic, erythematous-to-brownish papules and plaques on bilateral pretibial areas for 1.5 years. The lesions were significantly improved after 1 month of additional treatment with oral pentoxifylline. In this report, we aim to raise awareness in recognizing PPPD since it manifests unique clinical, dermoscopic, and histological features, representing pretibial skin’s response to chronic rubbing. In addition, we proposed a novel effective therapy for the disease using pentoxifylline.

show abstract

“…Pentoxifylline (PTF), an analogue of the methylxanthine theobromine, is a hemorheological agent with primary actions that include increasing erythrocyte flexibility, reducing blood viscosity and increasing microcirculatory flow and tissue perfusion, which improves the supply of oxygen to the ischemic muscles of the limbs [224,225]. PTF was initially developed for use in patients with intermittent claudication due to chronic occlusive arterial disease of the extremities.…”

Section: Peripheral Vasodilator (Pentoxifylline)mentioning

confidence: 99%

Pharmacotherapy for Keloids and Hypertrophic Scars

Murakami,

Shigeki

2024

IJMS

View full text Add to dashboard Cite

Keloids (KD) and hypertrophic scars (HTS), which are quite raised and pigmented and have increased vascularization and cellularity, are formed due to the impaired healing process of cutaneous injuries in some individuals having family history and genetic factors. These scars decrease the quality of life (QOL) of patients greatly, due to the pain, itching, contracture, cosmetic problems, and so on, depending on the location of the scars. Treatment/prevention that will satisfy patients’ QOL is still under development. In this article, we review pharmacotherapy for treating KD and HTS, including the prevention of postsurgical recurrence (especially KD). Pharmacotherapy involves monotherapy using a single drug and combination pharmacotherapy using multiple drugs, where drugs are administered orally, topically and/or through intralesional injection. In addition, pharmacotherapy for KD/HTS is sometimes combined with surgical excision and/or with physical therapy such as cryotherapy, laser therapy, radiotherapy including brachytherapy, and silicone gel/sheeting. The results regarding the clinical effectiveness of each mono-pharmacotherapy for KD/HTS are not always consistent but rather scattered among researchers. Multimodal combination pharmacotherapy that targets multiple sites simultaneously is more effective than mono-pharmacotherapy. The literature was searched using PubMed, Google Scholar, and Online search engines.

show abstract

Pentoxifylline in dermatology

Cited by 4 publications

References 77 publications

A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris

A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris

Pretibial Pruritic Papular Dermatitis: A Case Report and Emphasis on Effective Treatment with Pentoxifylline

Pharmacotherapy for Keloids and Hypertrophic Scars

Contact Info

Product

Resources

About