Pentoxifylline Maintains Hepatocellular Function and Improves Cardiac Performance during Early Sepsis

Wang, Haichao; Zf, Ba; Ih, Chaudry

doi:10.1097/00005373-199703000-00010

Cited by 23 publications

(12 citation statements)

References 22 publications

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“…Pentoxifylline increases hepatic glutathione levels and reduces the production of oxygen radicals [61]. Additionally, pentoxifylline is well known to improve tissue oxygenation via its vasodilator effect and to restore hepatocellular function [62,63]. Therefore, these aforementioned findings could provide a number of auxiliary explanatory mechanisms for improvement of NAFLD and for decreasing both HA and TGF-b1 levels in NAFLD patients including patients with steatosis with or without inflammation and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease

El-Haggar

Mostafa

2015

Hepatol Int

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Section: Discussionmentioning

confidence: 99%

Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease

El-Haggar

Mostafa

2015

Hepatol Int

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“…A PE-50 catheter in the right carotid artery was carefully advanced into the left ventricle. The position of the catheter was confirmed by restoring the analyzed form in an in vivo heart performance analyzer (Micro-Med) as described in our previous publications (34). Various left ventricular performance parameters, such as the maximal rate of the pressure increase (ϩdP/dt max ) and decrease (ϪdP/dt max ), were determined using a heart performance analyzer.…”

Section: Methodsmentioning

confidence: 99%

Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage

Mizushima

Wang

Jarrar

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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Although studies have shown that induction of the heat shock proteins (HSPs), such as HSP-70, has various beneficial effects after ischemia-reperfusion, it remains unknown whether prior induction of HSP-70 has any salutary effects on cardiovascular and hepatocellular functions after trauma-hemorrhage and resuscitation. Male rats were exposed to heat stress (41 degrees C, 15 min) and then allowed to recover for 24 h at room temperature (21 degrees C). The rats then underwent laparotomy (i.e., trauma induced) and were bled to and maintained at a mean arterial pressure of 40 mmHg until 40% of the maximal shed blood volume was returned in the form of Ringer lactate. Animals were then resuscitated with four times the volume of shed blood with Ringer lactate over 60 min. The maximal rate of the left ventricular pressure increase or decrease was measured up to 4 h after resuscitation. Cardiac output, hepatocellular function, plasma levels of tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were determined at 4 h after resuscitation. Cardiac and hepatic tissue were examined for HSP-70 by Western blot analysis. Left ventricular performance, cardiac output, and hepatocellular function decreased significantly following trauma-hemorrhage. Plasma levels of TNF-alpha and IL-6 were also significantly increased. However, prior heat stress attenuated cardiovascular and hepatocellular dysfunction, decreased circulating levels of proinflammatory cytokines following trauma-hemorrhage, and was associated with an increased abundance of HSP-70 in the heart and liver. Our data, therefore, suggest that preinduction of HSP-70 protects cardiovascular and hepatocellular functions following trauma-hemorrhage and resuscitation.

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“…CBV was then calculated according to our previous publication [17]. Moreover, heart performance parameters such as the maximal rate of the left ventricular pressure increase (ϩdP/dt max ) and decrease (ϪdP/dt max ) were determined using a heart performance analyzer (Digit-Med, Louisville, KY) as reported [18].…”

Section: Methodsmentioning

confidence: 99%

The Important Role of the Gut in Initiating the Hyperdynamic Response during Early Sepsis

Yang

Koo

Chaudry

et al. 2000

Journal of Surgical Research

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Pentoxifylline Maintains Hepatocellular Function and Improves Cardiac Performance during Early Sepsis

Abstract: Pentoxifylline appears to be a useful adjunct for maintaining hepatocellular function and improving cardiac performance during the early hyperdynamic stages of polymicrobial sepsis.

Cited by 23 publications

References 22 publications

Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease

Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease

Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage

The Important Role of the Gut in Initiating the Hyperdynamic Response during Early Sepsis

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