Pentraxin 3 and atherosclerosis among type 2 diabetic patients

Nabrdalik, Katarzyna; Chodkowski, A; Bartman, Wojciech; Tomasik, Andrzej; Kwiendacz, Hanna; Sawczyn, Tomasz; Kukla, Michał; Grzeszczak, W; Gumprecht, Janusz

doi:10.1515/biol-2017-0010

Cited by 3 publications

(11 citation statements)

References 19 publications

(24 reference statements)

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“…In presented study, the mean values of CCA ITM max in a group of patients with diabetic retinopathy were considerably below the cut-off value for the presence of atherosclerotic plaque (1.5 mm) and in spite of it, there was a significant correlation between it and PTX3 concentration. On this basis, there can be a conclusion drawn that PTX3 may be associated with the early stages of atherosclerosis in patients with diabetic retinopathy [21]. To our best knowledge, this is the first attempt to assess the association between PTX3 concentration and impaired systolic and diastolic cardiac function in a group of patients with diabetic retinopathy and it turned out that in this group of patients affected by left ventricle diastolic dysfunction there is a higher PTX3 plasma concentration comparing to patients without diabetic retinopathy, but the difference is not significant.…”

Section: Discussionmentioning

confidence: 96%

“…Plasma pentraxin 3 concentration, haemoglobin A 1c value, cholesterol and triglycerides, serum creatinine and urinary albumin secretion were measured. More detailed description of the study and laboratory examination methods were described previously [21]. All statistical analysis were performed using STATISTICA 12.5 (StatSoft, Poland).…”

Section: Methodsmentioning

confidence: 99%

“…We have previously examined the association of plasma PTX3 concentration with atherosclerosis in carotid arteries, systolic and diastolic left ventricle function and diabetes control among type 2 diabetic patients in relation to patients without glucose metabolism disorders [21]. This research is a follow up study where we evaluated biochemical, carotid and cardiac ultrasound parameters in the group of diabetic patients dived on the basis of the presence of diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

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Pentraxin 3 and retinopathy among type 2 diabetic patients in relation to carotid atherosclerosis and systolic and diastolic cardiac function — a pilot study

Chodkowski

Nabrdalik

Kwiendacz

et al. 2018

Clinical Diabetology

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Introduction. Diabetic retinopathy (DR) is the leading cause of vision loss worldwide. Global prevalence of any diabetic retinopathy is assessed to be 35.4%. Several studies proved that chronic low-grade inflammation may be involved in the pathogenesis of DR. Some studies indicate that macroangiopathic diabetic complications may be associated with microangiopathic ones that is why a "common soil" mechanism of diabetic micro-and macroangiogpathy has been proposed. The aim of this study was to evaluate the association of pentraxin 3 (PTX3), an inflammation's biomarker, with diabetic retinopathy in relation to atherosclerosis in carotid arteries and systolic and diastolic cardiac function. Material and methods. 43 eligible patients with type 2 diabetes were enrolled into the study and dived into two groups on the basis of presence or lack of retinopathy. Anthropometric, biochemical and carotid as well as cardiac ultrasound parameters were analyzed. Results. There was no direct association between PTX3 concentration and the presence of diabetic retinopathy, but there was a significant correlation between PTX3 and HbA 1c value, age and IMT (intima media thickness) in carotid arteries among patients with diabetic retinopathy. Conclusions. There is a great need for further, larger, studies on inflammatory biomarkers such as PTX3 and micro and macrovascular complications of diabetes mellitus in order to detect predisposed patients early enough to implement early therapeutic intervention of this complication.

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Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pentraxin 3 and retinopathy among type 2 diabetic patients in relation to carotid atherosclerosis and systolic and diastolic cardiac function — a pilot study

Chodkowski

Nabrdalik

Kwiendacz

et al. 2018

Clinical Diabetology

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“…Уровень PTX-3 исследован у больных СД 2 типа и макрососудистыми осложнениями [40]. Обращает на себя внимание, что сывороточный уровень биомаркера достоверно ассоциирован с ИМТ, скоростью клубочковой фильтрации, диастолической дисфункцией левого желудочка и мужским полом.…”

Section: сосудистый эндотелиальный фактор ростаunclassified

New directions in metabolic syndrome diagnosis: assessment of vascular endothelial growth factor, pentraxin-3 and transforming growth factor beta levels

Shepel

Драпкина

2019

Cardiovasc Ther Prev

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ФГБУ "Национальный медицинский исследовательский центр профилактической медицины" Минздрава России. Москва, Россия В статье представлены результаты отечественных и зарубежных клинических исследований, посвященных изучению уровня маркеров ангиогенеза-сосудистый эндотелиальный фактор роста, пентраксин-3 и трансформирующий фактор роста бета, у пациентов с метаболическим синдромом. Ключевые слова: метаболический синдром, ангиогенез, сосудистый эндотелиальный фактор роста, пентраксин-3, трансформирующий фактор роста бета. Конфликт интересов: не заявлен.

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“…Elevated plasma levels of PTX3 have been found in patients with high systolic and diastolic blood pressures and in elderly hypertensive patients [12] . Elevated concentration of PTX3 was found inside atherosclerotic plaques, which suggests that PTX3 can be an early marker of arteriosclerotic vascular damage [18] . Plasma PTX3 levels are increased in patients with carotid stenosis [19] .…”

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confidence: 93%

Value of Plasma Pentraxin 3 (Ptx3) Levels in Predicting Asymptomatic Preclinical Hypertensive-Related Atherosclerotic Vascular Disease in Egyptian Patients With Primary Hypertension

Hasaneen¹,

Abdelmoniem²,

Abed-Galil³

et al. 2020

IJAR

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Background: Pentraxins are generally considered acute phase proteins. Pentraxin 3 (PTX3), a long pentraxin, has been identified as an inflammatory biomarker, and its blood levels increase rapidly and dramatically in inflammatory conditions. Elevated plasma PTX3 levels were reported in patients with high systolic and diastolic blood pressures, and PTX3 can be an early marker of arteriosclerotic vascular damage. Carotid artery intima-media thickness (cIMT) is a well-established surrogate marker for subclinical atherosclerosis. However, the association between biomarkers of systemic inflammation and atherosclerosis progression in carotid artery is not well established. Aim of Study: Was to evaluate the value of plasma PTX3 level as a predictor for asymptomatic preclinical hypertensive-related atherosclerotic vascular disease. Subjects and Methods: 75 patients with primary hypertension who had no history or manifestations suggesting atherosclerotic vascular disease and 15 healthy subjects (control group) were included. Full history taking and thorough medical examination were done. Patients' weight, height, BMI, and blood pressure were assessed. Laboratory investigations (urine analysis, UACR, CBC, ESR, CRP, liver enzymes, urea, creatinine, blood sugar levels, HbA1c, uric acid, LDL cholesterol, HDL cholesterol, triglyceride, and PTX3 levels), ECG, echocardiography, and carotid ultrasonography (for measuring cIMT) were performed for all patients. Results: The mean age of patients was 54.7±9.3 years (range, 38-73 years). Asymptomatic preclinical atherosclerotic vascular disease, as reflected by cIMT > 0.1cm, was reported in 39 patients (52%). Hypertensive patients with LDL cholesterol ≥ 100mg/dL or with HDL cholesterol < 50mg/dL for males and < 40mg/dL for females had significantly higher plasma PTX3 levels. Higher degrees of UACR and albuminuria were associated with significantly elevated plasma PTX3 levels. Plasma PTX3 levels were significantly higher in hypertensive patients with preclinical atherosclerotic vascular disease,

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Pentraxin 3 and atherosclerosis among type 2 diabetic patients

Cited by 3 publications

References 19 publications

Pentraxin 3 and retinopathy among type 2 diabetic patients in relation to carotid atherosclerosis and systolic and diastolic cardiac function — a pilot study

Pentraxin 3 and retinopathy among type 2 diabetic patients in relation to carotid atherosclerosis and systolic and diastolic cardiac function — a pilot study

New directions in metabolic syndrome diagnosis: assessment of vascular endothelial growth factor, pentraxin-3 and transforming growth factor beta levels

Value of Plasma Pentraxin 3 (Ptx3) Levels in Predicting Asymptomatic Preclinical Hypertensive-Related Atherosclerotic Vascular Disease in Egyptian Patients With Primary Hypertension

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