Pentraxin-3 in COPD: innocent bystander or amplifier?

Mantovani, Alberto

doi:10.1183/09031936.00198111

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…These results indicate the lack of selection of cells relevant for PTX3 production at the chosen anatomical sites. In other words, PTX3 levels reflect selective degradation or post-transcriptional regulation [ 33 ]. Other significant functions of target genes of miR-208b and miR-378 focus on the metabolic process.…”

Section: Resultsmentioning

confidence: 99%

Prediction of microRNA and gene target from an integrated network in chronic obstructive pulmonary disease based on canonical correlation analysis

Hua

Xia

et al. 2018

THC

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BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex disorder with a high mortality. The pathophysiology of COPD has not been characterized till date.OBJECTIVE:To identify COPD-related biomarkers by a bioinformatics analysis.METHODS:Here, we conducted the canonical correlation analysis to extract the potential COPD-related miRNAs and mRNAs based on the miRNA-mRNA dual expression profiling data. After identifying miRNAs and mRNAs related to COPD, we constructed an interaction network by integrating three validated miRNA-target sources. Then we expanded the network by adding miRNA-mRNA pairs, which were identified by Spearman rank correlation test. For miRNAs involved in the network, we further performed the Gene Ontology (GO) functional enrichment analysis of their targets. To validate COPD-related mRNAs involved in the network, we performed receiver operating characteristic (ROC) curve analysis and Support Vector Machine (SVM) classification on only those mRNAs that overlapped with COPD-related mRNAs of Online Mendelian Inheritance in Man (OMIM) database. RESULTS:The results indicate that some identified miRNAs and their targets in the constructed network might be potential biomarkers of COPD.CONCLUSIONS: Our study helps us to predict the potential risk biomarkers of COPD, and it can certainly help in further elucidating the genetic etiology of COPD.

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Section: Resultsmentioning

confidence: 99%

Prediction of microRNA and gene target from an integrated network in chronic obstructive pulmonary disease based on canonical correlation analysis

Hua

Xia

et al. 2018

THC

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Pentraxin 3 as a Novel Biomarker of Inflammation in Chronic Obstructive Pulmonary Disease

2014

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Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease of the lungs in which inflammatory markers are involved with significant extrapulmonary effects that may contribute to its severity and complications. Moreover, some of the inflammatory markers such as C-reactive protein (CRP) are associated with COPD. Pentraxin 3 (PTX3) is the member of long pentraxins. The aim of the present study was to investigate the level of PTX3 in patients with COPD. Fifty-four COPD patients and 31 controls were enrolled in this study. Demographical data such as age, sex, cigarette smoking status, comorbidities, drugs, habits, and modified Medical Research Council (MMRC) dyspnea scores were recorded. All patients were asked for COPD Assessment Test™ (CAT). The mean age was 65.7 ± 9.8 years, 92 % male. Plasma levels of PTX3 were found to be markedly higher in COPD patients [1.65 (0.32-12.72) ng/ml] than in controls [1.05 (0.43-3.26) ng/ml; p = 0.005]. On the other hand, PTX3 values did not differ between COPD stages [A, 1.73 (0.69-11.03); B, 1.49 (0.84-12.52); C, 0.79 (0.52-1.06); and D, 2.09 (0.32-12.72); p = 0.27]. The plasma PTX3 levels were positively correlated with MMRC scores. We conclude that circulating PTX3 levels are elevated in COPD patients. Plasma levels of PTX3 were correlated with dyspnea (MMRC scores). But PTX3 levels were not correlated with the severity of COPD.

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Pentraxin 3 sputum levels differ in patients with chronic obstructive pulmonary disease vs asthma

Schwingel

Pizzichini

Kleveston

et al. 2015

Annals of Allergy, Asthma & Immunology

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Pentraxin-3 in COPD: innocent bystander or amplifier?

Cited by 5 publications

References 18 publications

Prediction of microRNA and gene target from an integrated network in chronic obstructive pulmonary disease based on canonical correlation analysis

Prediction of microRNA and gene target from an integrated network in chronic obstructive pulmonary disease based on canonical correlation analysis

Pentraxin 3 as a Novel Biomarker of Inflammation in Chronic Obstructive Pulmonary Disease

Pentraxin 3 sputum levels differ in patients with chronic obstructive pulmonary disease vs asthma

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