Pentraxin-3, Interleukin-6, and Acute Appendicitis: Biomarkers That Need Further Exploration

Abstract

Acute appendicitis is one of the most common abdominal emergencies that present in the hospital. With acute appendicitis, there is always a possibility of complications of perforation and peritonitis. Even though medicine has advanced substantially in different investigational modalities, appendicitis is confirmed clinically with the aid of a clinical approach (i.e., Alvarado Score), laboratory, and investigational modalities. However, biomarkers such as pentraxin-3 and interleukin-6 have been recently researched to assess the possibility of confirming the diagnosis of acute appendicitis in both adults and the pediatric age group. This article breaks down the previous research on pentraxin-3 and interleukin-6 biomarkers in relation to appendicitis and proposes a new hypothetical way of confirming the diagnosis.

Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis

“…Only six full-texts were assessed for eligibility. One of them was further excluded as it was a review article [ 11 ]. Therefore, only five studies were included in the final meta-analysis [ 1 , 2 , 12 – 14 ].…”

Apendectomías negativas en el servicio de cirugía general del Hospital Dr. Rafael Hernández L.

“…Interleucina6 y Pentraxina3: se ha reporta do la inducción de la fase inflamatoria agu da de la apendicitis por IL6, a su vez, la pentraxina3 se ha asociado a sitios infla matorios secundarios a numerosas citoqui nas, incluyendo la IL6 [14,15].…”