Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis

Kabbani, Dima; Bhaskaran, Abhishek; Singer, Lianne G.; Bhimji, Alyajahan; Rotstein, Coleman; Keshavjee, Shaf; Liles, W. Conrad; Husain, Shahid

doi:10.1016/j.healun.2017.04.007

Cited by 33 publications

(18 citation statements)

References 22 publications

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“…Specifically, PTX3 single-nucleotide polymorphisms (SNPs) were reported to be associated with IPA in patients undergoing haematopoietic stem-cell transplantation (HSCT), and BALF PTX3 in HSCT patients with invasive aspergillosis (IA) was significantly higher than in those without IA [12], which strengthens an association between PTX3 and IA. Kabbani et al obtained similar results in lung transplant recipients with IA [13]. Furthermore, our recent study indicated that plasma PTX3 was significantly higher in COPD patients with IPA, and fewer COPD patients with chronic pulmonary aspergillosis (CPA) had plasma PTX3 that was not significantly greater than that in the controls.…”

Section: Introductionsupporting

confidence: 67%

Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis

Liu

Zhou

et al. 2019

Clinical Microbiology and Infection

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Section: Introductionsupporting

confidence: 67%

Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis

Liu

Zhou

et al. 2019

Clinical Microbiology and Infection

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“…Patients with pulmonary aspergillosis, tuberculosis, dengue virus infection, meningococcal disease leptospirosis and shigellosis have increased PTX3 plasma levels that correlate with disease severity and could act as predictor of unfavorable outcomes (13, 49–51, 59, 61). PTX3 levels in plasma and bronchoalveolar lavage fluids (BALF) discriminate patients with invasive aspergillosis from those with other conditions, including lung cancer, community-acquired pneumonia (CAP), pulmonary cryptococcosis and Aspergillus fumigatus colonization (62, 63). Circulating levels of PTX3 were associated with SOFA (sequential organ failure assessment) score and case fatality in patients with bacteremia caused by Staphylococcus aureus, Streptococcus pneumoniae , β-hemolytic streptococcae or Escherichia coli (53).…”

Section: Ptx3 In Human Infectionsmentioning

confidence: 99%

The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

et al. 2019

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The first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity. PTX3, the first long pentraxin identified, is a soluble pattern recognition molecule rapidly produced by several cell types in response to primary pro-inflammatory signals and microbial recognition. PTX3 acts as an important mediator of innate immunity against pathogens of fungal, bacterial and viral origin, and as a regulator of inflammation, by modulating complement activation and cell extravasation, and facilitating pathogen recognition by myeloid cells. In sepsis, PTX3 plasma levels are associated with severity of the condition, patient survival, and response to therapy. In combination with other established biomarkers, PTX3 could improve stratification of sepsis patients and thus, complement the system of classification and monitoring of this disease.

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“…The risk of fungal infection after lung transplantation is high. Fungal infection directly induces the occurrence of relevant complications after surgery and is closely correlated with the mortality of recipients in the perioperative period after lung transplantation (1,2). According to a study (3), the occurrence rate of fungal infection among patients with lung transplantation is approximately at 15-35%, and more than 80% of them are mainly induced by Candida and Aspergillus.…”

Section: Introductionmentioning

confidence: 99%

Fungal infection in lung transplant recipients in perioperative period from one lung transplant center

Qiao¹,

Zou²,

Ping³

et al. 2019

J. Thorac. Dis

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Background: This study aimed to analyze the distribution and prophylaxis strategy of pathogens causing fungal infection in lung transplant recipients from cardiac-brain dead donors in the perioperative period to provide evidence for antifungal prophylaxis and treatment in lung transplant recipients. Methods: This retrospective study evaluated 194 lung transplant recipients from January 2015 to December 2016. Fungal pathogens were isolated and identified from respiratory tract cultures before and after transplantation in the perioperative period. The galactomannan (GM) testing of bronchoalveolar lavage fluid (BALF) might facilitate the diagnosis of Aspergillus infection. Data were statistically analyzed using SPSS 19.0. Results: A total of 31 cases of fungal strains isolated from the 194 recipients were identified prior to lung transplantation, and the positive rate was 16.0% (31/194). A total of 27 cases of isolated fungal strains in the 194 recipients were identified, and the positive rate after lung transplantation was 13.9% (27/194) in the perioperative period. A total of 54 cases with positive fungal infection (27.8%) were detected before and after lung transplantation. Overall, 10.3% (20/194) of the lung transplant recipients developed fungal infection in the observation period. The most common fungal pathogens were filamentous fungi and Candida albicans. Conclusions: Our data suggested that fungi were frequently isolated before and after transplantation from respiratory samples. However, the incidence of invasive fungal infection in lung transplant recipients in the perioperative period was relatively low. Targeted antifungal prophylaxis and treatment should be applied on the basis of the fungal distribution status of different individuals.

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Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis

Cited by 33 publications

References 22 publications

Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis

Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis

The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

Fungal infection in lung transplant recipients in perioperative period from one lung transplant center

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