Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus

Increased hippocampal T2 in a rat model of pentylenetetrazol-induced kindling correlates with seizure scores

“…4A). These findings agreed well with previous results showing that repeated PTZ treatments can result in progressive hippocampal neuronal loss [16,25,29,30]. Neuronal loss was most severe in the CA1 of the kindled rats (Fig.…”

Seizure suppression through manipulating splicing of a voltage-gated sodium channel

“…It is no surprise, therefore, that cyclin/CDKs have been implicated in epileptogenesis. For example, cyclin B1 upregulation is observed in the hippocampus of pentylenetetrazole (PTZ)-kindled rats (Pavlova et al , 2006) and patients with temporal lobe epilepsy (Nagy and Esiri, 1998). Similarly, administration of kainite (KA) upregulates cyclin D1 expression in wild-type mice and loss of one copy of cyclin D1 ( cyclin D1 +/ − heterozygous mice) prevents kainite-induced seizure (Liu et al , 1996; Timsit et al , 1999; Koeller et al , 2008).…”

Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

“…It has been suggested that release of excitatory neurotransmitters such as glutamate and aspartate as well as neuronal transmembrane ion flux may lead to tissue perturbation and production of dark neurons [36,38,39]. Excessive excitability, glutamate release and elevation of intracellular calcium due to seizure induced by PTZ may cause cell death [39,40]. In the present study, anise oil prevented production of dark neurons by inhibition of seizure attacks and, therefore, may act as a neuroprotective substance.…”