Riskesdas data in 2021 shows that only 52.5% or half of 2.3 million of 1-6 month babies in Indonesia who get exclusive breastfeeding. Most provinces still has low percentage of exclusive breastfeed and under the national average. One of the factors is due to the unhealthy condition of the mother and due to the lack of confidence when giving exclusive breastfeeding. Giving therapy massage that combines oxytocin with other therapies becomes a specialized intervention to assist mothers in producing exclusively breast milk. This literature reviews aimed to know the effectiveness of Oxytocin Massage for increasing Milk production. The literature review employed PRISMA method. The database used Scopus, PubMed, Science Direct, EBSCO, PROQUEST, NILITI, and Google Scholar. The key words were included Mother AND Oxytocin OR massage Oxytocin AND Breast milk AND RCT. The inclusion criteria used were RCT articles 2017 to 2022, using English and Indonesian, full text and the exclusion criteria such as reviewed, unoriginal publications including a letter to the editor, abstracts only, and books. An assessment tool of critical JBI was used to evaluate the quality of journal. The result showed that the Oxytocin Massage with or without a combination of other therapies can help mothers to have an exclusive breast milk production