People with epilepsy receive more statins than the general population but have no higher cardiovascular risk: results from a cross‐sectional study

Vivanco-Hidalgo, Rosa María; Elosúa, Roberto; González, Agustín; Moreira, Antía; Díez, Laura González; Grau, María; Dégano, Irene R.; Roquer, Jaume

doi:10.1111/ene.13222

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…Based on previous research 41 , the three CVD major risk factors were defined as follows: diabetes as the use of hypoglycemic agents, a self-reported history of diabetes, or a FPG ≥ 7.0 mmol/L or more 37 ; hypertension as resting SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg and/or the self-reported current treatment for hypertension with antihypertensive medication 42 ; dyslipidemia as using lipid-lowering drugs or having one or more of the following: TG ≥ 1.7 mmol/L, TC ≥ 5.18 mmol/L, HDL-C < 1.04 mmol/L, and LDL-C ≥ 3.37 mmol/L 43 .…”

Section: Methodsmentioning

confidence: 99%

The increased risk of sarcopenia in patients with cardiovascular risk factors in Suburb-Dwelling older Chinese using the AWGS definition

Han

et al. 2017

Sci Rep

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The aim of the present study is to investigate the relationship between sarcopenia and cardiovascular risk factors (CVRF) in the Chinese elderly. A total of 1611 elderly individuals aged ≥60 years were enrolled in this study. The well-established CVRF of diabetes, hypertensions, and dyslipidemia were assessed. Sarcopenia was defined according to the recommended algorithm of the Asian Working Group for Sarcopenia (AWGS). Multiple logistic regression analyses and the linear regressions were used to evaluate the components of CVRF and the number of CVRF of elderly patients with sarcopenia. After adjusting for potential confounders, CVRF was associated with a high prevalence of sarcopenia in elderly Chinese populations. Furthermore, diabetes and hypertension, but not dyslipidemia, were found to be significantly associated with sarcopenia. The OR and 95% CI for sarcopenia of the participants with 1, 2, and 3 features of CVRF were 2.27(1.14–4.48), 4.13(1.80–9.46), and 4.90(1.01–23.81), respectively. A linear increase in the prevalence of sarcopenia was found to be associated with the number of CVRF components in the elderly population (P values for the trends < 0.001). Knowledge of known CVRF, particularly diabetes and hypertension, may help predict the risk for sarcopenia in the elderly.

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Section: Methodsmentioning

confidence: 99%

The increased risk of sarcopenia in patients with cardiovascular risk factors in Suburb-Dwelling older Chinese using the AWGS definition

Han

et al. 2017

Sci Rep

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“…In contrast, a study by Vicanco-Hidalgo et al [33] concluded that, despite a higher percentage of dyslipidemia in epileptic patients, they do not have a greater cardiovascular risk. In the above study compared to healthy people, epileptic individuals had a lower rate of hypertension and diabetes [33], what indicates the need for a better assessment of epileptic patients prior to statin treatment. In our study, patients were treated with various antiepileptic drugs, both in mono-and polytherapy.…”

Section: Discussionmentioning

confidence: 85%

“…In some studies, the monotherapy with old-generation drugs, such as carbamazepine, valproic acid, and phenytoin, was associated with an increase in cardiovascular risk [32]. In contrast, a study by Vicanco-Hidalgo et al [33] concluded that, despite a higher percentage of dyslipidemia in epileptic patients, they do not have a greater cardiovascular risk. In the above study compared to healthy people, epileptic individuals had a lower rate of hypertension and diabetes [33], what indicates the need for a better assessment of epileptic patients prior to statin treatment.…”

Section: Discussionmentioning

confidence: 99%

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Kulesza

Cyuńczyk

Kochanowicz

et al. 2020

Preprint

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Background: Several factors predispose people with epilepsy to cardiovascular diseases. Among them nutrition and lifestyle have not been sufficiently studied. Methods. The study involved 60 epileptic male and female volunteers and 70 healthy controls, corresponding to age and gender. Medical information was collected during the study and a detailed questionnaire survey concerning eating and lifestyle habits was conducted. Physical activity was evaluated using International Physical Activity Questionnaire (IPAQ). Nutritional status was assessed by bioelectric impedance. Venous blood samples were taken for lipid and 25-hydroxyvitamin D3 (25(OH)D3) analyses. Results. A tendency to an increase in LDL cholesterol was found in epileptics. Significantly higher body fat and insignificantly higher visceral fat was found in epileptic men compared to healthy men. In epileptic women a tendency to lower lean body mass was found. Patients with epilepsy were more sedentary, had lower consumption of cottage cheese, fruit, pulses, nuts and seeds, vitamin C and potassium, and higher intake of sugar-sweetened soda, energy from fat and sodium compared to healthy people. As a positive point, epileptics consumed less coffee and alcoholic beverages. More than 80% of diets of epilepsy people were low in folic acid, vitamin D and calcium, but similar tendency was observed in the healthy people. The diets of patients with epilepsy were in a higher percentage poor in niacin, vitamin C and potassium compared to the control group, 25% to 7%, 50% to 31% and 73 to 56% respectively. A significantly lower serum concentration of 25(OH)D3 was observed in epileptic individuals, which in this group was found to be positively modulated by physical activity.Conclusions. The study indicates that several behavior-related habits, which may predispose epileptic people to cardiovascular disease, need to be improved. For this reason, patients with epilepsy should be provided with more comprehensive medical care, including advice on nutrition and physical activity.

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“…We defined the same four signatures for cardiometabolic risk factors in 2008 and 2017 (also see online supplementary table 1): (1) Obesity: BMI≥28 kg/m 21–23. (2) Hypertension: blood pressure ≥140/90 mm Hg and/or self-reported history of hypertension 24. (3) Dyslipidaemia: LDL-C ≥4.14 mmol/L and/or self-reported dyslipidaemia 25.…”

Section: Methodsmentioning

confidence: 99%

Time trend of cardiometabolic risk factors over a 10-year period in the office-working population in China

et al. 2019

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ObjectivesRecent dramatic increases in cardiovascular disease mortality in China can be mostly explained by adverse changes in hypertension, dyslipidaemia, diabetes and obesity, known as cardiometabolic risk factors. Our study aimed to assess the trend of these four signatures by a 10-year lag in Nanjing, China.Methods8017 subjects attended the routine health examination in 2008, and 9379 subjects in 2017, from multiple work units of Nanjing, were included in the present study. The prevalence and trend of four cardiometabolic risk factors: hypertension, dyslipidaemia, diabetes and obesity were analysed.ResultsFrom 2008 to 2017, the prevalence of hypertension declined, while the prevalence of dyslipidaemia, diabetes and obesity increased. Besides, the population in 2008 and 2017 had an average of 0.66 and 0.78 risk factors, respectively.ConclusionCardiometabolic risk factors are common for the staff in administrative agencies and institutions of Nanjing, China. Effective screening and interventions against these risk factors should be adopted in high-risk populations such as the office-working population in China.

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People with epilepsy receive more statins than the general population but have no higher cardiovascular risk: results from a cross‐sectional study

Cited by 10 publications

References 29 publications

The increased risk of sarcopenia in patients with cardiovascular risk factors in Suburb-Dwelling older Chinese using the AWGS definition

The increased risk of sarcopenia in patients with cardiovascular risk factors in Suburb-Dwelling older Chinese using the AWGS definition

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Time trend of cardiometabolic risk factors over a 10-year period in the office-working population in China

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